About   Help   FAQ
Gsc2 Gene Detail
Summary
  • Symbol
    Gsc2
  • Name
    goosecoid homebox 2
  • Synonyms
    4930568H22Rik, Gscl
Location &
Maps
more
  • Sequence Map
    Chr16:17730978-17732891 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.10 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892006
 protein coding gene Chr16:17730971-17732923 (-)
129S1/SvImJ ENSMUSG00200041465
 protein coding gene Chr16:14727540-14729492 (-)
A/J ENSMUSG00195031317
 protein coding gene Chr16:14284832-14286784 (-)
AKR/J ENSMUSG00220045428
 protein coding gene Chr16:14601086-14603038 (-)
BALB/cJ ENSMUSG00180029794
 protein coding gene Chr16:14526068-14528020 (-)
C3H/HeJ ENSMUSG00175049740
 protein coding gene Chr16:14671078-14673032 (-)
C57BL/6NJ ENSMUSG00215040326
 protein coding gene Chr16:14392196-14394148 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020533
 protein coding gene Chr16:14407200-14409188 (-)
CAST/EiJ ENSTCUG00005044068
 protein coding gene Chr16:14609485-14611500 (-)
CBA/J ENSMUSG00210046658
 protein coding gene Chr16:14687399-14689353 (-)
DBA/2J ENSMUSG00185029495
 protein coding gene Chr16:14633550-14635502 (-)
FVB/NJ ENSMUSG00205042797
 protein coding gene Chr16:14641172-14643124 (-)
JF1/MsJ ENSUMUG00000051420
 protein coding gene Chr16:14723854-14725878 (-)
LP/J ENSMUSG00230042149
 protein coding gene Chr16:17211413-17213365 (-)
NOD/ShiLtJ ENSMUSG00190048618
 protein coding gene Chr16:14773455-14775407 (-)
NZO/HlLtJ ENSMUSG00225036522
 protein coding gene Chr16:20457254-20459206 (-)
PWK/PhJ ENSLUMG00010039871
 protein coding gene Chr16:14597735-14599691 (-)
SPRET/EiJ ENSMSPG00010036056
 protein coding gene Chr16:14615632-14617613 (-)
WSB/EiJ ENSIUOG00005033390
 protein coding gene Chr16:14767497-14769475 (-)



Homology
more
  • Human Ortholog
    GSC2, goosecoid homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSC2, goosecoid homeobox 2
  • Synonyms
    GSCL
  • Links
    NCBI Gene ID: 2928
    UniProt: O15499

  • Chr Location
    22q11.21; chr22:19146993-19150292 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    159 phenotype references
Mice homozygous for either one of two independently generated knock-out alleles are viable and fertile with no detectable anatomical or histological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    138
  • cDNA Data
    14
  • Literature Summary
    16
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 195333 NCBI Gene Model | MGI Sequence Detail 1914 C57BL/6J ±  kb
transcript NM_029469 RefSeq | MGI Sequence Detail 1133 Not Specified  
polypeptide P56916 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    Genomic 27
    cDNA 14
    Primer pair 10
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923125
References
more
  • Summaries
    All 204
    Developmental Gene Expression 16
    Diseases 6
    Gene Ontology 8
    Phenotypes 159
  • Earliest
    J:32846 Halford S, et al., Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet. 1993 Dec;2(12):2099-107
  • Latest
    J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory