About   Help   FAQ
Phyh Gene Detail
Summary
  • Symbol
    Phyh
  • Name
    phytanoyl-CoA hydroxylase
  • Synonyms
    Lnap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891978
    NCBI Gene: 16922
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4923830-4943541 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    611 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891978
 protein coding gene Chr2:4923807-4943554 (+)
129S1/SvImJ ENSMUSG00200030478
 protein coding gene Chr2:1790268-1809982 (+)
A/J ENSMUSG00195016112
 protein coding gene Chr2:1899326-1919047 (+)
AKR/J ENSMUSG00220005110
 protein coding gene Chr2:1890837-1910557 (+)
BALB/cJ ENSMUSG00180030718
 protein coding gene Chr2:1992624-2012276 (+)
C3H/HeJ ENSMUSG00175015648
 protein coding gene Chr2:1889290-1909001 (+)
C57BL/6NJ ENSMUSG00215012581
 protein coding gene Chr2:2013940-2033656 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023146
 protein coding gene Chr2:1748451-1771741 (+)
CAST/EiJ ENSTCUG00005004614
 protein coding gene Chr2:1863978-1890312 (+)
CBA/J ENSMUSG00210027544
 protein coding gene Chr2:1929574-1949280 (+)
DBA/2J ENSMUSG00185011923
 protein coding gene Chr2:1889076-1908791 (+)
FVB/NJ ENSMUSG00205021260
 protein coding gene Chr2:1876422-1896124 (+)
JF1/MsJ ENSUMUG00000001531
 protein coding gene Chr2:1873561-1893772 (+)
LP/J ENSMUSG00230002499
 protein coding gene Chr2:3838303-3858015 (+)
NOD/ShiLtJ ENSMUSG00190005602
 protein coding gene Chr2:1891219-1910937 (+)
NZO/HlLtJ ENSMUSG00225001157
 protein coding gene Chr2:11565481-11585197 (+)
PWK/PhJ ENSLUMG00010029237
 protein coding gene Chr2:1929838-1949397 (+)
SPRET/EiJ ENSMSPG00010024905
 protein coding gene Chr2:1886748-1905825 (+)
WSB/EiJ ENSIUOG00005021402
 protein coding gene Chr2:1885176-1904865 (+)



Homology
more
  • Human Ortholog
    PHYH, phytanoyl-CoA 2-hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHYH, phytanoyl-CoA 2-hydroxylase
  • Synonyms
    LN1, LNAP1, PAHX, PHYH1, RD
  • Links
    NCBI Gene ID: 5264
    UniProt: O14832

  • Chr Location
    10p13; chr10:13277796-13302412 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Phyh mouse models; 4 with human PHYH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When fed a high phytol diet, mice homozygous for a null allele exhibit hepatic lipidosis and steatosis, ataxia, peripheral neuropathy and loss of spermatogonia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    143
  • cDNA Data
    173
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026664 Ensembl Gene Model | MGI Sequence Detail 19712 C57BL/6J ±  kb
    transcript ENSMUST00000027975 Ensembl | MGI Sequence Detail 1438 Not Applicable  
    polypeptide ENSMUSP00000027975 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 173
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138869, MGI:2138872
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 16
      Phenotypes 15
    • Earliest
      J:37950 Iwano M, et al., Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse. Biochem Biophys Res Commun. 1996 Dec 4;229(1):355-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory