Crygd MGI Mouse Gene Detail - MGI:88524

Symbol

Crygd
Name

crystallin, gamma D
Synonyms

Aey4, Cryg-1, DGcry-1

Feature Type

protein coding gene
IDs

MGI:88524
NCBI Gene: 12967
Member of

Cryg cluster
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:65101031-65102611 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.80 cM
Mapping Data

12 experiments

SNPs within 2kb

56 from dbSNP Build 142
Strain Annotations

17
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88524	protein coding gene	Chr1:65101001-65102611 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016102	protein coding gene	Chr1:65254001-65255583 (-)
A/J	MGP_AJ_G0016085	protein coding gene	Chr1:62957858-62959440 (-)
AKR/J	MGP_AKRJ_G0016042	protein coding gene	Chr1:64720525-64722107 (-)
BALB/cJ	MGP_BALBcJ_G0016040	protein coding gene	Chr1:63053707-63055196 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0016493	protein coding gene	Chr1:67783981-67784687 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014214	protein coding gene	Chr1:59011759-59013316 (-)
CAST/EiJ	MGP_CASTEiJ_G0015455	protein coding gene	Chr1:64261441-64262247 (-)
CBA/J	MGP_CBAJ_G0015844	protein coding gene	Chr1:69986073-69987655 (-)
DBA/2J	MGP_DBA2J_G0015945	protein coding gene	Chr1:62360238-62361008 (-)
FVB/NJ	MGP_FVBNJ_G0015948	protein coding gene	Chr1:61633240-61634758 (-)
LP/J	MGP_LPJ_G0016017	protein coding gene	Chr1:66153881-66156149 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015968	protein coding gene	Chr1:72836036-72837964 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016540	protein coding gene	Chr1:64704060-64707644 (-)
PWK/PhJ	MGP_PWKPhJ_G0015241	protein coding gene	Chr1:61759320-61760055 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015021	protein coding gene	Chr1:64189771-64191820 (-)
WSB/EiJ	MGP_WSBEiJ_G0015517	protein coding gene	Chr1:64409879-64414133 (-)

Human Ortholog

CRYGD, crystallin gamma D

Vertebrate Orthologs

18

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYGD, crystallin gamma D
Synonyms

CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC
Links

HGNC:2411

NCBI Gene ID: 1421

neXtProt AC: NX_P07320

UniProt: P07320
Chr Location

2q33.3; chr2:208121607-208124524 (-) GRCh38

MGI Vertebrate Homology

Crygd stringent orthology
1 human;1 mouse;1 rat;16 zebrafish
HCOP

vertebrate homology predictions: CRYGD
Gene Tree

Crygd

Diseases

2 with Crygd mouse models; 2 with human CRYGD associations

Human Disease

Mouse Models

cataract 4 multiple types

IDs

View 2 models

cataract 2 multiple types

IDs

View 1 model

cataract 7

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

8 phenotypes from 6 alleles in 4 genetic backgrounds
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

4
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Spontaneous

2
Targeted

5
Genomic Mutations

2 involving Crygd
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

902
Tissues

37
cDNA Data

141
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS35599.1

Ensembl

ENSMUSG00000067299 (Evidence)
NCBI Gene

12967

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067299	Ensembl Gene Model \| MGI Sequence Detail	1581	C57BL/6J	± kb
transcript	ENSMUST00000045028	Ensembl \| MGI Sequence Detail	613	Not Applicable
polypeptide	ENSMUSP00000045327	Ensembl \| MGI Sequence Detail	174	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005917 gamma-crystallin D

(term hierarchy)
InterPro Domains

IPR001064 Beta/gamma crystallin

IPR011024 Gamma-crystallin-like

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All nucleic 148

cDNA 143

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-11853, MGD-MRK-2170, MGD-MRK-2179, MGD-MRK-8836, MGI:96805

Summaries

All 70

Developmental Gene Expression 22

Diseases 2

Gene Ontology 6

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:339482 Schmid PWN, et al., Imbalances in the eye lens proteome are linked to cataract formation. Nat Struct Mol Biol. 2021 Feb;28(2):143-151

TSS for Crygd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11961	Chr1:65102596-65102599 (-)	13 bp
Tssr11960	Chr1:65101342-65101353 (-)	1,263 bp
Tssr11959	Chr1:65101257-65101277 (-)	1,344 bp
Tssr11958	Chr1:65101080-65101085 (-)	1,528 bp
Tssr11957	Chr1:65101049-65101060 (-)	1,556 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23