Cpa3 MGI Mouse Gene Detail - MGI:88479 - carboxypeptidase A3, mast cell

Symbol

Cpa3
Name

carboxypeptidase A3, mast cell
Synonyms

mast cell carboxypeptidase A, MC-CPA, mMC-CPA

Feature Type

protein coding gene
IDs

MGI:88479
NCBI Gene: 12873
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:20269784-20296345 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 6.25 cM
Mapping Data

4 experiments

SNPs within 2kb

196 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88479	protein coding gene	Chr3:20269780-20296373 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027101	protein coding gene	Chr3:17444711-17472559 (-)
A/J	MGP_AJ_G0027061	protein coding gene	Chr3:17348764-17376553 (-)
AKR/J	MGP_AKRJ_G0027030	protein coding gene	Chr3:17545991-17572561 (-)
BALB/cJ	MGP_BALBcJ_G0027073	protein coding gene	Chr3:17094573-17121813 (-)
C3H/HeJ	MGP_C3HHeJ_G0026814	protein coding gene	Chr3:17551786-17578886 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027518	protein coding gene	Chr3:18540285-18570282 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024880	protein coding gene	Chr3:15398448-15425976 (-)
CAST/EiJ	MGP_CASTEiJ_G0026269	protein coding gene	Chr3:17443446-17469905 (-)
CBA/J	MGP_CBAJ_G0026792	protein coding gene	Chr3:18948160-18982559 (-)
DBA/2J	MGP_DBA2J_G0026926	protein coding gene	Chr3:16955832-16987226 (-)
FVB/NJ	MGP_FVBNJ_G0026894	protein coding gene	Chr3:16618065-16644514 (-)
LP/J	MGP_LPJ_G0027038	protein coding gene	Chr3:18079350-18105279 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026915	protein coding gene	Chr3:21003432-21033942 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027578	protein coding gene	Chr3:17306863-17334889 (-)
PWK/PhJ	MGP_PWKPhJ_G0026002	protein coding gene	Chr3:16664921-16692939 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025812	protein coding gene	Chr3:17105930-17136412 (-)
WSB/EiJ	MGP_WSBEiJ_G0026342	protein coding gene	Chr3:17315266-17344351 (-)

Human Ortholog

CPA3, carboxypeptidase A3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPA3, carboxypeptidase A3
Synonyms

MC-CPA
Links

HGNC:2298

NCBI Gene ID: 1359

neXtProt AC: NX_P15088

UniProt: P15088
Chr Location

3q24; chr3:148865296-148897203 (+) GRCh38

MGI Vertebrate Homology

Cpa3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CPA3
Gene Tree

Cpa3

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 4 alleles in 6 genetic backgrounds
17 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Radiation induced

1
Targeted

6
Genomic Mutations

1 involving Cpa3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Homozygous null mice have immature peritoneal mast cells but normal mast cell functions.

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

18
cDNA Data

36
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS17262.1

Ensembl

ENSMUSG00000001865 (Evidence)
NCBI Gene

12873

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001865	Ensembl Gene Model \| MGI Sequence Detail	26562	C57BL/6J	± kb
transcript	ENSMUST00000001921	Ensembl \| MGI Sequence Detail	1449	Not Applicable
polypeptide	ENSMUSP00000001921	Ensembl \| MGI Sequence Detail	417	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005797 mast cell carboxypeptidase A

(term hierarchy)
EC

3.4.17.1
InterPro Domains

IPR003146 Carboxypeptidase, activation peptide

IPR036990 Metallocarboxypeptidase-like, propeptide

IPR000834 Peptidase M14, carboxypeptidase A

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All nucleic 43

Genomic 2

cDNA 38

Primer pair 3

Microarray probesets 3

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MGD-MRK-2103

Summaries

All 82

Developmental Gene Expression 7

Diseases 1

Gene Ontology 6

Phenotypes 44
Earliest

J:10117 Reynolds DS, et al., Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25;264(33):20094-9
Latest

J:341732 Lin CJ, et al., Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice. Cell Rep. 2023 Sep 26;42(9):113141

TSS for Cpa3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32713	Chr3:20296353-20296362 (-)	-13 bp
Tssr32712	Chr3:20296337-20296351 (-)	1 bp
Tssr32711	Chr3:20296322-20296331 (-)	18 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23