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Comp Gene Detail
Summary
  • Symbol
    Comp
  • Name
    cartilage oligomeric matrix protein
  • Synonyms
    thrombospondin-5, TSP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88469
    NCBI Gene: 12845
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70826208-70834716 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88469
 protein coding gene Chr8:70826186-70834721 (+)
129S1/SvImJ ENSMUSG00200030513
 protein coding gene Chr8:65623660-65632248 (+)
A/J ENSMUSG00195013255
 protein coding gene Chr8:65957027-65965535 (+)
AKR/J ENSMUSG00220022007
 protein coding gene Chr8:65869103-65877691 (+)
BALB/cJ ENSMUSG00180025517
 protein coding gene Chr8:65600061-65608651 (+)
C3H/HeJ ENSMUSG00175021416
 protein coding gene Chr8:65880015-65888604 (+)
C57BL/6NJ ENSMUSG00215032005
 protein coding gene Chr8:65559528-65568036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031143
 protein coding gene Chr8:62585120-62593542 (+)
CAST/EiJ ENSTCUG00005036255
 protein coding gene Chr8:65355902-65364432 (+)
CBA/J ENSMUSG00210032041
 protein coding gene Chr8:65645576-65654165 (+)
DBA/2J ENSMUSG00185010529
 protein coding gene Chr8:71805192-71813781 (+)
FVB/NJ ENSMUSG00205024741
 protein coding gene Chr8:65149793-65158382 (+)
JF1/MsJ ENSUMUG00000031864
 protein coding gene Chr8:74085460-74093968 (+)
LP/J ENSMUSG00230032610
 protein coding gene Chr8:75416754-75425343 (+)
NOD/ShiLtJ ENSMUSG00190021317
 protein coding gene Chr8:65566669-65575177 (+)
NZO/HlLtJ ENSMUSG00225048052
 protein coding gene Chr8:78825901-78834490 (+)
PWK/PhJ ENSLUMG00010032521
 protein coding gene Chr8:65542991-65551494 (+)
SPRET/EiJ ENSMSPG00010033352
 protein coding gene Chr8:67233054-67241617 (+)
WSB/EiJ ENSIUOG00005023459
 protein coding gene Chr8:66436648-66445244 (+)



Homology
more
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Synonyms
    CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5, TSP5
  • Links
    NCBI Gene ID: 1311
    UniProt: P49747

  • Chr Location
    19p13.11; chr19:18782773-18791305 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Comp mouse models; 4 with human COMP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    65
  • cDNA Data
    22
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031849 Ensembl Gene Model | MGI Sequence Detail 8509 C57BL/6J ±  kb
    transcript ENSMUST00000003659 Ensembl | MGI Sequence Detail 2416 Not Applicable  
    polypeptide ENSMUSP00000003659 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 22
      Primer pair 4
      Other 1
      Antibodies 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2091
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 29
      Diseases 4
      Gene Ontology 27
      Phenotypes 32
    • Earliest
      J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
    • Latest
      J:386556 Peters AA, et al., Age and Sex Impact the Role of Thrombospondin-2 and Thrombospondin-5 in Response to Hindlimb Ischemia. FASEB Bioadv. 2026 Feb;8(2):e70087
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory