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Col15a1 Gene Detail
Summary
  • Symbol
    Col15a1
  • Name
    collagen, type XV, alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88449
    NCBI Gene: 12819
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:47208161-47313167 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 26.01 cM, cytoband B1-B3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88449
protein coding gene Chr4:47207744-47313167 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028266
protein coding gene Chr4:45576935-45687889 (+)
A/J MGP_AJ_G0028225
protein coding gene Chr4:43863950-43968979 (+)
AKR/J MGP_AKRJ_G0028175
protein coding gene Chr4:44974843-45079859 (+)
BALB/cJ MGP_BALBcJ_G0028245
protein coding gene Chr4:43986364-44091250 (+)
C3H/HeJ MGP_C3HHeJ_G0027966
protein coding gene Chr4:45561548-45676434 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028686
protein coding gene Chr4:47252506-47367006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025995
protein coding gene Chr4:41245484-41349891 (+)
CAST/EiJ MGP_CASTEiJ_G0027405
protein coding gene Chr4:45152203-45256503 (+)
CBA/J MGP_CBAJ_G0027932
protein coding gene Chr4:48755151-48873287 (+)
DBA/2J MGP_DBA2J_G0028082
protein coding gene Chr4:43770411-43875458 (+)
FVB/NJ MGP_FVBNJ_G0028049
protein coding gene Chr4:43035456-43141209 (+)
LP/J MGP_LPJ_G0028181
protein coding gene Chr4:45632645-45743081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028073
protein coding gene Chr4:51793207-51914638 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028721
protein coding gene Chr4:45194774-45306231 (+)
PWK/PhJ MGP_PWKPhJ_G0027130
protein coding gene Chr4:43878262-43985819 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026958
protein coding gene Chr4:44702626-44808901 (+)
WSB/EiJ MGP_WSBEiJ_G0027483
protein coding gene Chr4:45117572-45227196 (+)



Homology
more
  • Human Ortholog
    COL15A1, collagen type XV alpha 1 chain
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COL15A1, collagen type XV alpha 1 chain
  • Links
    NCBI Gene ID: 1306
    neXtProt AC: NX_P39059
    UniProt: P39059

  • Chr Location
    9q22.33; chr9:98943179-99070787 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal muscle cells of variable size (including atrophic and split muscle cells), susceptibility to exercise-induced muscle injury, and abnormalities in heart and skeletal muscle capillary endothelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028339 Ensembl Gene Model | MGI Sequence Detail 105007 C57BL/6J ±  kb
    transcript ENSMUST00000102917 Ensembl | MGI Sequence Detail 5172 Not Applicable  
    polypeptide ENSMUSP00000099981 Ensembl | MGI Sequence Detail 1367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 2
      cDNA 98
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2056
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 18
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:15411 Abe N, et al., Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region. Biochem Biophys Res Commun. 1993 Oct 29;196(2):576-82
    • Latest
      J:343095 Honeycutt SE, et al., Netrin 1 directs vascular patterning and maturity in the developing kidney. Development. 2023 Nov 15;150(22)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory