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C4bp Gene Detail
Summary
  • Symbol
    C4bp
  • Name
    complement component 4 binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:88229
    NCBI Gene: 12269
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130562510-130589365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88229
 protein coding gene Chr1:130562510-130589369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016436
 protein coding gene Chr1:134020683-134050145 (-)
A/J MGP_AJ_G0016419
 protein coding gene Chr1:129068931-129096051 (-)
AKR/J MGP_AKRJ_G0016384
 protein coding gene Chr1:132866623-132900793 (-)
BALB/cJ MGP_BALBcJ_G0016379
 protein coding gene Chr1:129401649-129428451 (-)
C3H/HeJ MGP_C3HHeJ_G0016205
 protein coding gene Chr1:133008131-133034915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016840
 protein coding gene Chr1:139010851-139038324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014554
 protein coding gene Chr1:122222919-122248322 (-)
CAST/EiJ MGP_CASTEiJ_G0015785
 protein coding gene Chr1:131994866-132024096 (-)
CBA/J MGP_CBAJ_G0016177
 protein coding gene Chr1:143794171-143826035 (-)
DBA/2J MGP_DBA2J_G0016284
 protein coding gene Chr1:128032616-128059607 (-)
FVB/NJ MGP_FVBNJ_G0016283
 protein coding gene Chr1:126677264-126704186 (-)
LP/J MGP_LPJ_G0016355
 protein coding gene Chr1:135337183-135365112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016308
 protein coding gene Chr1:149569117-149606299 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016876
 protein coding gene Chr1:132635601-132663397 (-)
PWK/PhJ MGP_PWKPhJ_G0015571
 protein coding gene Chr1:127001102-127028437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015358
 protein coding gene Chr1:131556818-131586612 (-)
WSB/EiJ MGP_WSBEiJ_G0015847
 protein coding gene Chr1:132595425-132622226 (-)



Homology
more
  • Human Ortholog
    C4BPA, complement component 4 binding protein alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C4BPA, complement component 4 binding protein alpha
  • Synonyms
    C4BP, PRP
  • Links
    NCBI Gene ID: 722
    UniProt: P04003

  • Chr Location
    1q32.2; chr1:207104233-207144972 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C4BPA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice exhibit normal fertility and spermatozoa morphology and function. Mice homozygous for the same allele exhibit increase IL6 serum levels in response to LPS injection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    54
  • cDNA Data
    46
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12269 NCBI Gene Model | MGI Sequence Detail 26856 C57BL/6J ±  kb
    transcript NM_001419982 RefSeq | MGI Sequence Detail 3058 ZRU/MplStud  
    polypeptide P08607 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000030465 C4b-binding protein alpha chain
      (term hierarchy)
    • InterPro Domains
      IPR040514 C4b-binding protein alpha, oligomerization domain
      IPR051503 Complement System Regulators and Virion Entry Mediators
      IPR051277 SEZ6/CSMD/C4BPB Neuronal & Immune Regulators
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
    • GlyGen
      P08607 7 sites, 4 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 9
      cDNA 47
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1702, MGI:2138170
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory