Bmp6 MGI Mouse Gene Detail - MGI:88182 - bone morphogenetic protein 6

Symbol

Bmp6
Name

bone morphogenetic protein 6
Synonyms

D13Wsu115e, Vgr1

Feature Type

protein coding gene
IDs

MGI:88182
NCBI Gene: 12161
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr13:38529098-38684283 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 18.15 cM
Mapping Data

15 experiments

SNPs within 2kb

4243 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88182	protein coding gene	Chr13:38529083-38684283 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020472	protein coding gene	Chr13:36681491-36852595 (+)
A/J	MGP_AJ_G0020426	protein coding gene	Chr13:35522665-35674997 (+)
AKR/J	MGP_AKRJ_G0020404	protein coding gene	Chr13:36459415-36623112 (+)
BALB/cJ	MGP_BALBcJ_G0020422	protein coding gene	Chr13:35622799-35776590 (+)
C3H/HeJ	MGP_C3HHeJ_G0020221	protein coding gene	Chr13:36295721-36452137 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020855	protein coding gene	Chr13:37894324-38052013 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018442	protein coding gene	Chr13:33702743-33856475 (+)
CAST/EiJ	MGP_CASTEiJ_G0019736	protein coding gene	Chr13:36071012-36229204 (+)
CBA/J	MGP_CBAJ_G0020182	protein coding gene	Chr13:39485053-39653689 (+)
DBA/2J	MGP_DBA2J_G0020304	protein coding gene	Chr13:35039624-35196627 (+)
FVB/NJ	MGP_FVBNJ_G0020283	protein coding gene	Chr13:34571056-34725771 (+)
LP/J	MGP_LPJ_G0020379	protein coding gene	Chr13:36934147-37097708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020313	protein coding gene	Chr13:39584167-39745669 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020898	protein coding gene	Chr13:36035639-36195143 (+)
PWK/PhJ	MGP_PWKPhJ_G0019491	protein coding gene	Chr13:35166269-35321869 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019322	protein coding gene	Chr13:34703350-34868206 (+)
WSB/EiJ	MGP_WSBEiJ_G0019798	protein coding gene	Chr13:36382884-36544182 (+)

Human Ortholog

BMP6, bone morphogenetic protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMP6, bone morphogenetic protein 6
Synonyms

IO, VGR, VGR1
Links

HGNC:1073

NCBI Gene ID: 654

UniProt: P22004
Chr Location

6p24.3; chr6:7726099-7881728 (+) GRCh38

MGI Vertebrate Homology

Bmp6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BMP6
Gene Tree

Bmp6

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

4
Genomic Mutations

1 involving Bmp6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.

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All GO Annotations

103
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1184
Tissues

302
cDNA Data

18
Literature Summary

110

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BMP6

Xenbase bmp6

ZFIN bmp6

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS26462.1

Ensembl

ENSMUSG00000039004 (Evidence)
NCBI Gene

12161

			Length	Strain/Species	Flank
genomic	12161	NCBI Gene Model \| MGI Sequence Detail	155186	C57BL/6J	± kb
transcript	NM_007556	RefSeq \| MGI Sequence Detail	3583	ZRU/MplStud
polypeptide	P20722	UniProt \| EBI \| MGI Sequence Detail	510	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000000167 bone morphogenetic protein 6

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR001111 TGF-beta, propeptide

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR015615 Transforming growth factor-beta-related
GlyGen

P20722 5 sites, 2 N-linked glycans (3 sites)

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All nucleic 45

Genomic 1

cDNA 22

Primer pair 11

Other 11

Microarray probesets 4

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MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333

Summaries

All 226

Developmental Gene Expression 110

Gene Ontology 24

Phenotypes 35
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:364447 Fisher AL, et al., The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice. Blood. 2025 Feb 6;145(6):625-634

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119362	Chr13:38529070-38529081 (+)	-22 bp
Tssr119363	Chr13:38529084-38529116 (+)	2 bp
Tssr119364	Chr13:38529126-38529135 (+)	33 bp
Tssr119365	Chr13:38534185-38534188 (+)	5,089 bp
Tssr4047	Chr13:38648611-38648623 (+)	119,519 bp

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Pbd2	Chr13, 12.94 cM	Chr13:17189508-38947406	J:77538	The authors report the construction of a reciprocal congenic strain, P2.P6-Pbd2. Strains SAMP6 and SAMP2 were used as the donor and recipient strains, respectively. Whereas Pbd2 is a QTL locus defined by bone mass. The Congenic strain carries a SAMP6-derived mouse Chromosome 13 osteoporosis susceptible interval within the SAMP2-derived osteoporosis resistance background. The Interval could be defined as being contained within proximal marker D13Mit303 and distal marker D13Mit177. Within this region gene Bmp6 resides which is suggested as a candidate gene for Pbd2.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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