Bmp6 MGI Mouse Gene Detail - MGI:88182 - bone morphogenetic protein 6

Symbol

Bmp6
Name

bone morphogenetic protein 6
Synonyms

D13Wsu115e, Vgr1

Feature Type

protein coding gene
IDs

MGI:88182
NCBI Gene: 12161
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:38529692-38684290 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 18.15 cM
Mapping Data

15 experiments

SNPs within 2kb

876 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88182	protein coding gene	Chr13:38529083-38684290 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020472	protein coding gene	Chr13:36681491-36852595 (+)
A/J	MGP_AJ_G0020426	protein coding gene	Chr13:35522665-35674997 (+)
AKR/J	MGP_AKRJ_G0020404	protein coding gene	Chr13:36459415-36623112 (+)
BALB/cJ	MGP_BALBcJ_G0020422	protein coding gene	Chr13:35622799-35776590 (+)
C3H/HeJ	MGP_C3HHeJ_G0020221	protein coding gene	Chr13:36295721-36452137 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020855	protein coding gene	Chr13:37894324-38052013 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018442	protein coding gene	Chr13:33702743-33856475 (+)
CAST/EiJ	MGP_CASTEiJ_G0019736	protein coding gene	Chr13:36071012-36229204 (+)
CBA/J	MGP_CBAJ_G0020182	protein coding gene	Chr13:39485053-39653689 (+)
DBA/2J	MGP_DBA2J_G0020304	protein coding gene	Chr13:35039624-35196627 (+)
FVB/NJ	MGP_FVBNJ_G0020283	protein coding gene	Chr13:34571056-34725771 (+)
LP/J	MGP_LPJ_G0020379	protein coding gene	Chr13:36934147-37097708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020313	protein coding gene	Chr13:39584167-39745669 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020898	protein coding gene	Chr13:36035639-36195143 (+)
PWK/PhJ	MGP_PWKPhJ_G0019491	protein coding gene	Chr13:35166269-35321869 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019322	protein coding gene	Chr13:34703350-34868206 (+)
WSB/EiJ	MGP_WSBEiJ_G0019798	protein coding gene	Chr13:36382884-36544182 (+)

Human Ortholog

BMP6, bone morphogenetic protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMP6, bone morphogenetic protein 6
Synonyms

IO, VGR, VGR1
Links

HGNC:1073

NCBI Gene ID: 654

neXtProt AC: NX_P22004

UniProt: P22004
Chr Location

6p24.3; chr6:7726778-7881728 (+) GRCh38.p7

Alliance of Genome Resources

Bmp6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BMP6
Gene Tree

Bmp6

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Bmp6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.

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All GO Annotations

63
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1181
Tissues

301
cDNA Data

18
Literature Summary

105

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BMP6

Xenbase bmp6

ZFIN bmp6

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Bmp6 interacts with 88 markers (Mir17, Mir18, Mir20b, ...) View All

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS26462.1

Ensembl

ENSMUSG00000039004 (Evidence)
NCBI Gene

12161

			Length	Strain/Species	Flank
genomic	12161	NCBI Gene Model \| MGI Sequence Detail	154599	C57BL/6J	± kb
transcript	NM_007556	RefSeq \| MGI Sequence Detail	3583	C57BL/6
polypeptide	P20722	UniProt \| EBI \| MGI Sequence Detail	510	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000000167 bone morphogenetic protein 6

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR001111 TGF-beta, propeptide

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR015615 Transforming growth factor-beta-related

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All nucleic 43

Genomic 1

cDNA 22

Primer pair 11

Other 9

Microarray probesets 4

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MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333

Summaries

All 212

Developmental Gene Expression 105

Gene Ontology 20

Phenotypes 33
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:324606 La Manno G, et al., Molecular architecture of the developing mouse brain. Nature. 2021 Aug;596(7870):92-96

TSS for Bmp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119362	Chr13:38529070-38529081 (+)	-616 bp
Tssr119363	Chr13:38529084-38529116 (+)	-592 bp
Tssr119364	Chr13:38529126-38529135 (+)	-561 bp
Tssr119365	Chr13:38534185-38534188 (+)	4,495 bp
Tssr4047	Chr13:38648611-38648623 (+)	118,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22