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Bmp5 Gene Detail
Summary
  • Symbol
    Bmp5
  • Name
    bone morphogenetic protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88181
    NCBI Gene: 12160
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75682646-75807592 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.34 cM
  • Mapping Data
    75 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3489 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88181
 protein coding gene Chr9:75682646-75807598 (+)
129S1/SvImJ ENSMUSG00200019022
 protein coding gene Chr9:72787502-72912482 (+)
A/J ENSMUSG00195010256
 protein coding gene Chr9:72554542-72683270 (+)
AKR/J ENSMUSG00220015007
 protein coding gene Chr9:72680986-72809683 (+)
BALB/cJ ENSMUSG00180017348
 protein coding gene Chr9:72667132-72795852 (+)
C3H/HeJ ENSMUSG00175010689
 protein coding gene Chr9:72703002-72831721 (+)
C57BL/6NJ ENSMUSG00215010867
 protein coding gene Chr9:72636801-72761829 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032447
 protein coding gene Chr9:72783950-72909714 (+)
CAST/EiJ ENSTCUG00005008846
 protein coding gene Chr9:72394297-72520532 (+)
CBA/J ENSMUSG00210013106
 protein coding gene Chr9:72757541-72886219 (+)
DBA/2J ENSMUSG00185006329
 protein coding gene Chr9:72787971-72916651 (+)
FVB/NJ ENSMUSG00205016348
 protein coding gene Chr9:73075193-73203876 (+)
JF1/MsJ ENSUMUG00000037744
 protein coding gene Chr9:72779530-72904961 (+)
LP/J ENSMUSG00230022779
 protein coding gene Chr9:72964355-73089302 (+)
NOD/ShiLtJ ENSMUSG00190032577
 protein coding gene Chr9:72882703-73011412 (+)
NZO/HlLtJ ENSMUSG00225025111
 protein coding gene Chr9:73085465-73214150 (+)
PWK/PhJ ENSLUMG00010015112
 protein coding gene Chr9:72708344-72833817 (+)
SPRET/EiJ ENSMSPG00010003834
 protein coding gene Chr9:73856381-73980138 (+)
WSB/EiJ ENSIUOG00005023959
 protein coding gene Chr9:72246972-72380967 (+)



Homology
more
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
  • Links
    NCBI Gene ID: 653
    UniProt: P22003

  • Chr Location
    6p12.1; chr6:55753653-55875595 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bmp5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 16 alleles in 19 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1006
  • Tissues
    230
  • cDNA Data
    44
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032179 Ensembl Gene Model | MGI Sequence Detail 124947 C57BL/6J ±  kb
    transcript ENSMUST00000012281 Ensembl | MGI Sequence Detail 3822 Not Applicable  
    polypeptide ENSMUSP00000012281 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 5
      cDNA 45
      Primer pair 11
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14349, MGD-MRK-1603, MGI:2143223
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 82
      Diseases 1
      Gene Ontology 13
      Phenotypes 70
    • Earliest
      J:14849 Lynch CJ, Short ears, an autosomal mutation in the house mouse. Am Naturalist. 1921;55:421-426
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory