Amd1 MGI Mouse Gene Detail - MGI:88004 - S-adenosylmethionine decarboxylase 1

Symbol

Amd1
Name

S-adenosylmethionine decarboxylase 1
Synonyms

AdoMetDC, Amd-1, SAMDC

Feature Type

protein coding gene
IDs

MGI:88004
NCBI Gene: 11702
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:40163454-40178184 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 21.85 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

13 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88004	protein coding gene	Chr10:40163454-40178184 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017162	protein coding gene	Chr10:38838385-38854933 (-)
A/J	MGP_AJ_G0017139	protein coding gene	Chr10:37796069-37808640 (-)
AKR/J	MGP_AKRJ_G0017099	protein coding gene	Chr10:38338737-38351202 (-)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0016922	protein coding gene	Chr10:38658442-38672537 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017560	protein coding gene	Chr10:40048971-40069505 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015256	protein coding gene	Chr10:35771383-35782255 (-)
CAST/EiJ	MGP_CASTEiJ_G0016501	protein coding gene	Chr10:38842894-38858993 (-)
CBA/J	MGP_CBAJ_G0016896	protein coding gene	Chr10:41879059-41895145 (-)
DBA/2J	MGP_DBA2J_G0017001	protein coding gene	Chr10:37314546-37328116 (-)
FVB/NJ	MGP_FVBNJ_G0016996	protein coding gene	Chr10:36814967-36865196 (-)
LP/J	MGP_LPJ_G0017078	protein coding gene	Chr10:38830388-38842093 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017026	protein coding gene	Chr10:42721163-42732856 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017597	protein coding gene	Chr10:38315494-38329076 (-)
PWK/PhJ	MGP_PWKPhJ_G0016281	protein coding gene	Chr10:37187449-37199886 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016065	protein coding gene	Chr10:38145402-38160888 (-)
WSB/EiJ	MGP_WSBEiJ_G0016564	protein coding gene	Chr10:38617913-38637919 (-)

Human Ortholog

AMD1, adenosylmethionine decarboxylase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMD1, adenosylmethionine decarboxylase 1
Synonyms

ADOMETDC, AMD, SAMDC
Links

HGNC:457

NCBI Gene ID: 262

neXtProt AC: NX_P17707

UniProt: P17707
Chr Location

6q21; chr6:110814617-110898879 (+) GRCh38

MGI Vertebrate Homology

Amd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AMD1
Protein SuperFamily

S-AdenosylMet_decarboxylase
Gene Tree

Amd1

Diseases

1 with human AMD1 associations

				Human Disease	Mouse Models
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Amd1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Homozygous null mice display embryonic lethality before somite formation and embryonic growth arrest.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

970
Tissues

120
cDNA Data

162
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase amd1

ZFIN amd1

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All Sequences

56
RefSeq

2
UniProt

4
CCDS

CCDS48544.1

Ensembl

ENSMUSG00000075232 (Evidence)
NCBI Gene

11702

			Length	Strain/Species	Flank
genomic	11702	NCBI Gene Model \| MGI Sequence Detail	14731	C57BL/6J	± kb
transcript	NM_009665	RefSeq \| MGI Sequence Detail	3206	ZRU/MplStud
polypeptide	P0DMN7	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000035207 S-adenosylmethionine decarboxylase proenzyme 1

(term hierarchy)
EC

4.1.1.50
InterPro Domains

IPR018166 S-adenosylmethionine decarboxylase, conserved site

IPR016067 S-adenosylmethionine decarboxylase, core

IPR001985 S-adenosylmethionine decarboxylase, eukaryotes

IPR048283 S-adenosylmethionine decarboxylase-like

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All nucleic 166

Genomic 2

cDNA 163

Primer pair 1

Microarray probesets 10

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MGD-MRK-1293, MGD-MRK-1294

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Amd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97385	Chr10:40178182-40178202 (-)	-8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23