Adss MGI Mouse Gene Detail - MGI:87948 - adenylosuccinate synthetase, non muscle

Symbol

Adss
Name

adenylosuccinate synthetase, non muscle
Synonyms

AS

Feature Type

protein coding gene
IDs

MGI:87948
NCBI Gene: 11566
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:177590742-177624275 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 82.81 cM
Mapping Data

3 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87948	protein coding gene	Chr1:177590528-177624275 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016850	protein coding gene	Chr1:183965513-184000762 (-)
A/J	MGP_AJ_G0016829	protein coding gene	Chr1:176530389-176571451 (-)
AKR/J	MGP_AKRJ_G0016795	protein coding gene	Chr1:181822228-181858039 (-)
BALB/cJ	MGP_BALBcJ_G0016786	protein coding gene	Chr1:177071859-177106026 (-)
C3H/HeJ	MGP_C3HHeJ_G0016612	protein coding gene	Chr1:182425335-182462519 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017251	protein coding gene	Chr1:189958024-189991514 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014957	protein coding gene	Chr1:167810041-167844253 (-)
CAST/EiJ	MGP_CASTEiJ_G0016193	protein coding gene	Chr1:181818592-181852993 (-)
CBA/J	MGP_CBAJ_G0016585	protein coding gene	Chr1:196899769-196938696 (-)
DBA/2J	MGP_DBA2J_G0016691	protein coding gene	Chr1:175400675-175435414 (-)
FVB/NJ	MGP_FVBNJ_G0016688	protein coding gene	Chr1:173487057-173520779 (-)
LP/J	MGP_LPJ_G0016766	protein coding gene	Chr1:185152425-185187358 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016719	protein coding gene	Chr1:204144759-204179829 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017287	protein coding gene	Chr1:181558743-181593098 (-)
PWK/PhJ	MGP_PWKPhJ_G0015980	protein coding gene	Chr1:174487520-174521329 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015757	protein coding gene	Chr1:180664436-180697793 (-)
WSB/EiJ	MGP_WSBEiJ_G0016255	protein coding gene	Chr1:181767666-181803217 (-)

Human Ortholog

ADSS2, adenylosuccinate synthase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADSS2, adenylosuccinate synthase 2
Synonyms

ADEH, ADSS, ADSS 2
Links

HGNC:292

NCBI Gene ID: 159

neXtProt AC: NX_P30520

UniProt: P30520
Chr Location

1q44; chr1:244408492-244452134 (-) GRCh38.p7

Alliance of Genome Resources

Adss stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADSS2
Gene Tree

Adss

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

10
Targeted

7
Genomic Mutations

2 involving Adss
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

96
cDNA Data

144
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adss2

less

Adss interacts with 205 markers (Mir1a-1, Mir1a-2, Mir10a, ...) View All

less

All Sequences

47
RefSeq

3
UniProt

3
CCDS

CCDS15555.1

Ensembl

ENSMUSG00000015961 (Evidence)
NCBI Gene

11566

			Length	Strain/Species	Flank
genomic	11566	NCBI Gene Model \| MGI Sequence Detail	33534	C57BL/6J	± kb
transcript	NM_007422	RefSeq \| MGI Sequence Detail	2553	C57BL/6
polypeptide	P46664	UniProt \| EBI \| MGI Sequence Detail	456	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000003795 adenylosuccinate synthetase isozyme 2

(term hierarchy)
EC

6.3.4.4
InterPro Domains

IPR033128 Adenylosuccinate synthase, active site

IPR018220 Adenylosuccinate synthase, GTP-binding site

IPR001114 Adenylosuccinate synthetase

IPR042109 Adenylosuccinate synthetase, domain 1

IPR042110 Adenylosuccinate synthetase, domain 2

IPR042111 Adenylosuccinate synthetase, domain 3

IPR027529 Adenylosuccinate synthetase isozyme 2, chordates

IPR027417 P-loop containing nucleoside triphosphate hydrolase

less

All nucleic 146

Genomic 1

cDNA 145

Microarray probesets 5

less

MGD-MRK-1165, MGI:2138197

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 16
Earliest

J:306719 Swain JL, et al., Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction. J Clin Invest. 1984 Oct;74(4):1422-7
Latest

J:330042 Luo XM, et al., The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression. Commun Biol. 2022 Oct 12;5(1):1088

TSS for Adss:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15461	Chr1:177624282-177624291 (-)	-12 bp
Tssr15460	Chr1:177624259-177624266 (-)	12 bp
Tssr315	Chr1:177624253-177624256 (-)	20 bp
Tssr15459	Chr1:177624240-177624243 (-)	33 bp
Tssr15458	Chr1:177624229-177624239 (-)	41 bp
Tssr15457	Chr1:177624203-177624214 (-)	66 bp
Tssr15456	Chr1:177624176-177624185 (-)	94 bp
Tssr15455	Chr1:177624101-177624112 (-)	168 bp
Tssr15454	Chr1:177624017-177624080 (-)	226 bp
Tssr15453	Chr1:177623980-177623999 (-)	285 bp
Tssr15452	Chr1:177623070-177623076 (-)	1,202 bp
Tssr15451	Chr1:177604158-177604173 (-)	20,109 bp
Tssr15450	Chr1:177600974-177600979 (-)	23,298 bp
Tssr15449	Chr1:177591257-177591268 (-)	33,012 bp
Tssr15448	Chr1:177590978-177591006 (-)	33,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22