Cirbil Gene Detail

Summary

• Symbol
  Cirbil
• Name
  cardiac injury related BCLAF1-inhibiting lncRNA
• Synonyms
  lncCIRBIL

• Feature Type
  lincRNA gene
  BioType Conflict
  
• IDs
  MGI:6828806
  NCBI Gene: 123477722
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr6:108895915-108915647 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  681 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_6828806	lincRNA gene	Chr6:108845241-108915786 (-)
129S1/SvImJ	ENSMUSG00200026442	lncRNA gene	Chr6:105952822-105968711 (-)
A/J	ENSMUSG00195017763	lncRNA gene	Chr6:105568006-105597857 (-)
AKR/J	ENSMUSG00220037739	lncRNA gene	Chr6:104476543-104506409 (-)
BALB/cJ	ENSMUSG00180002385	lncRNA gene	Chr6:105941024-105970899 (-)
C3H/HeJ	ENSMUSG00175017210	lncRNA gene	Chr6:71408659-71463101 (+)
C57BL/6NJ	ENSMUSG00215026202	lncRNA gene	Chr6:105967129-105987529 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005030775	lncRNA gene	Chr6:105851934-105868141 (-)
CBA/J	ENSMUSG00210020964	lncRNA gene	Chr6:105797826-105827684 (-)
DBA/2J	ENSMUSG00185018850	lncRNA gene	Chr6:106239142-106255693 (-)
FVB/NJ	ENSMUSG00205026744	lncRNA gene	Chr6:104899854-104915745 (-)
JF1/MsJ	ENSUMUG00000029107	lncRNA gene	Chr6:104988593-105005160 (-)
LP/J	no annotation
NOD/ShiLtJ	ENSMUSG00190018529	lncRNA gene	Chr6:105402055-105422445 (-)
NZO/HlLtJ	ENSMUSG00225005921	lncRNA gene	Chr6:109379373-109384163 (-)
PWK/PhJ	ENSLUMG00010028196	lncRNA gene	Chr6:104483322-104499748 (-)
SPRET/EiJ	ENSMSPG00010015102	lncRNA gene	Chr6:107095026-107111312 (-)
WSB/EiJ	ENSIUOG00005025535	lncRNA gene	Chr6:106194281-106217110 (-)

Homology

• Gene Tree
  Cirbil
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit increased susceptibility to ischemia/reperfusion injury.

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  1

• Ensembl
  ENSMUSG00000120743 (Evidence)
• NCBI Gene
  123477722

Representative Sequences			Length	Strain/Species
genomic	123477722	NCBI Gene Model | MGI Sequence Detail	19733	C57BL/6J
transcript	NR_173999	RefSeq | MGI Sequence Detail	862	C57BL/6

Other
Accession IDs

MGI:7337891

References

• Summaries
  All 6

  Phenotypes 1
• Earliest
  J:301260 Zhang Y, et al., The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia-reperfusion injury. Nat Commun. 2021 Jan 22;12(1):522
• Latest
  J:339952 Jiang Y, et al., Cytoplasmic sequestration of p53 by lncRNA-CIRPILalleviates myocardial ischemia/reperfusion injury. Commun Biol. 2022 Jul 18;5(1):716

TSS for Cirbil:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62396	Chr6:108915627-108915668 (-)	-1 bp