Tc(HSA21,CAG-EGFP)1Yakaz
Allele Detail

Summary

• Symbol: Tc(HSA21,CAG-EGFP)1Yakaz
• Name: transchromosomal, human 21, line 1, Yasuhiro Kazuki
• MGI ID: MGI:6386757
• Synonyms: Tc(HSA21q;MAC)1Yakaz, TcMAC21
• Transgene: Tc(HSA21,CAG-EGFP)1Yakaz Location: unknown
• Alliance: Tc(HSA21,CAG-EGFP)1Yakaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297246
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Not Applicable (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: Mouse artificial chromosome (MAC) technology cloned the 34 MB long arm of HSA21 (HSA21q). The MAC transgene contains a CAG promoter driving the EGFP reporter gene flanked by HS4 insulators, a PGK-neomycin cassette, loxP-3'HPRT site, PGK-puromycin cassette, and telomeres. Line 1 was generated. (J:297246)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:297246 Kazuki Y, et al., A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. Elife. 2020 Jun 29;9:e56223
• All: 5 reference(s)