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Trappc10 Gene Detail
Summary
  • Symbol
    Trappc10
  • Name
    trafficking protein particle complex 10
  • Synonyms
    B230307C21Rik, b2b2416Clo, b2b2613Clo, LOC380642, Tmem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336209
    NCBI Gene: 216131
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78022559-78080475 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1404 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336209
 protein coding gene Chr10:78021256-78080479 (-)
129S1/SvImJ ENSMUSG00200048367
 protein coding gene Chr10:74700672-74758590 (-)
A/J ENSMUSG00195048277
 protein coding gene Chr10:75037324-75095247 (-)
AKR/J ENSMUSG00220045759
 protein coding gene Chr10:74697021-74754934 (-)
BALB/cJ ENSMUSG00180052433
 protein coding gene Chr10:75051714-75109632 (-)
C3H/HeJ ENSMUSG00175051561
 protein coding gene Chr10:74922825-74980742 (-)
C57BL/6NJ ENSMUSG00215050330
 protein coding gene Chr10:74660583-74718500 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015506
 protein coding gene Chr10:72223474-72282316 (-)
CAST/EiJ ENSTCUG00005046823
 protein coding gene Chr10:74537393-74595431 (-)
CBA/J ENSMUSG00210043441
 protein coding gene Chr10:74778951-74836869 (-)
DBA/2J ENSMUSG00185047941
 protein coding gene Chr10:75121292-75179214 (-)
FVB/NJ ENSMUSG00205044810
 protein coding gene Chr10:74813322-74871242 (-)
JF1/MsJ ENSUMUG00000055094
 protein coding gene Chr10:76281191-76339427 (-)
LP/J ENSMUSG00230045757
 protein coding gene Chr10:76890778-76948697 (-)
NOD/ShiLtJ ENSMUSG00190051543
 protein coding gene Chr10:75098729-75156647 (-)
NZO/HlLtJ ENSMUSG00225044842
 protein coding gene Chr10:81178551-81236481 (-)
PWK/PhJ ENSLUMG00010049996
 protein coding gene Chr10:74665152-74723655 (-)
SPRET/EiJ ENSMSPG00010046706
 protein coding gene Chr10:76448027-76506241 (-)
WSB/EiJ ENSIUOG00005046329
 protein coding gene Chr10:74698109-74756005 (-)



Homology
more
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex subunit 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex subunit 10
  • Synonyms
    EHOC-1, EHOC1, GT334, NEDMISS, TMEM1, TRS130, TRS30
  • Links
    NCBI Gene ID: 7109
    UniProt: P48553

  • Chr Location
    21q22.3; chr21:44012309-44106553 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Trappc10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    27 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cardiovascular phenotypes, including atrioventricular or ventricular septal defects, thymus hypoplasia, and eye defects such as microphthalmia or anophthalmia. Holoprosencephaly, anencephaly and severe craniofacial defects may be also present.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    136
  • cDNA Data
    93
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000374 Ensembl Gene Model | MGI Sequence Detail 57917 C57BL/6J ±  kb
    transcript ENSMUST00000000384 Ensembl | MGI Sequence Detail 5047 Not Applicable  
    polypeptide ENSMUSP00000000384 Ensembl | MGI Sequence Detail 1258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016612 trafficking protein particle complex subunit 10
      (term hierarchy)
    • InterPro Domains
      IPR045126 Trafficking protein particle complex subunit TRAPPC10/Trs130
      IPR063087 TRAPPC10, first Ig-like domain
      IPR056917 TRAPPC10, Ig-like domain
      IPR063125 TRAPPC10, third Ig-like domain
      IPR056913 TRAPPC10/Trs130, N-terminal
      IPR063676 TRAPPC10/Trs130, NTS-like domain
    • GlyGen
      Q3TLI0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 8
      cDNA 95
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685716, MGI:3036257, MGI:5560780, MGI:5615090
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 8
      Phenotypes 45
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory