Gm38999 Gene Detail

Summary

• Symbol
  Gm38999
• Name
  predicted gene, 38999

• Feature Type
  protein coding gene
• IDs
  MGI:5621884
  NCBI Gene: 105242927
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr7:43077110-43078256 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  189 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5621884	protein coding gene	Chr7:43077094-43079260 (+)
129S1/SvImJ	ENSMUSG00200027666	protein coding gene	Chr7:30662719-30663865 (+)
A/J	ENSMUSG00195047985	protein coding gene	Chr7:34702846-34703992 (+)
AKR/J	ENSMUSG00220044684	protein coding gene	Chr7:29000963-29002109 (+)
BALB/cJ	ENSMUSG00180040772	protein coding gene	Chr7:31578361-31579507 (+)
C3H/HeJ	ENSMUSG00175025471	protein coding gene	Chr7:32098672-32099818 (+)
C57BL/6NJ	ENSMUSG00215042095	protein coding gene	Chr7:31368470-31369616 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005047368	protein coding gene	Chr7:35087171-35088334 (+)
CBA/J	ENSMUSG00210037417	protein coding gene	Chr7:32475430-32476576 (+)
DBA/2J	ENSMUSG00185046007	protein coding gene	Chr7:36338210-36339362 (+)
FVB/NJ	ENSMUSG00205045909	protein coding gene	Chr7:32020610-32021756 (+)
JF1/MsJ	ENSUMUG00000046411	protein coding gene	Chr7:40825120-40826272 (+)
LP/J	ENSMUSG00230048895	protein coding gene	Chr7:41782349-41783483 (+)
NOD/ShiLtJ	ENSMUSG00190045890	protein coding gene	Chr7:32342327-32343473 (+)
NZO/HlLtJ	ENSMUSG00225008345	protein coding gene	Chr7:39988490-39989636 (+)
PWK/PhJ	ENSLUMG00010036722	protein coding gene	Chr7:31252406-31253558 (+)
SPRET/EiJ	ENSMSPG00010032723	protein coding gene	Chr7:31058752-31060039 (+)
WSB/EiJ	ENSIUOG00005027813	protein coding gene	Chr7:32910728-32911874 (+)

Homology

• Human Ortholog
  C19orf84, chromosome 19 open reading frame 84

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  C19orf84, chromosome 19 open reading frame 84
  
• Links
  HGNC:27112

  NCBI Gene ID: 147646

  UniProt: I3L1E1

  
  
• Chr Location
  19q13.41; chr19:51388289-51390591 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gm38999 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: C19orf84
• Gene Tree
  Gm38999
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele exhibit male-specific infertility associated with testicular atrophy, azoospermia, arrest male meiosis at the early pachytene stage, increased male germ cell apoptosis, and abnormal DNA methylation during gametogenesis.

Expression

• Literature Summary
  2

• Other Mouse Links
  Expression Atlas
• Other Vertebrate Links
  Xenbase c7h19orf84

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS90216.1

• Ensembl
  ENSMUSG00000118553 (Evidence)
• NCBI Gene
  105242927

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000118553	Ensembl Gene Model | MGI Sequence Detail	1147	C57BL/6J
transcript	ENSMUST00000239023	Ensembl | MGI Sequence Detail	558	Not Applicable
polypeptide	ENSMUSP00000159166	Ensembl | MGI Sequence Detail	185	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000060168 piRNA-mediated silencing protein C19orf84
  (term hierarchy)
• InterPro Domains
  IPR040606 piRNA-mediated silencing protein C19orf84

References

• Summaries
  All 8

  Developmental Gene Expression 2

  Phenotypes 1
• Earliest
  J:346376 Zoch A, et al., C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line. Mol Cell. 2024 Mar 21;84(6):1021-1035.e11
• Latest
  J:387962 Chowdhury T, et al., A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation. Nature. 2026 Feb;650(8102):779-785