Discn Gene Detail

Summary

• Symbol
  Discn
• Name
  DNA damage-induced stem cell specific noncoding RNA
• Synonyms
  Gm38659

• Feature Type
  lncRNA gene
• IDs
  MGI:5621544
  NCBI Gene: 102643127
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr11:95026897-95028496 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  161 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5621544	lncRNA gene	Chr11:95026897-95030764 (-)
129S1/SvImJ	ENSMUSG00200052988	lncRNA gene	Chr11:92270242-92271560 (-)
A/J	ENSMUSG00195052635	lncRNA gene	Chr11:91991718-91993009 (-)
AKR/J	ENSMUSG00220052826	lncRNA gene	Chr11:92250648-92251939 (-)
BALB/cJ	ENSMUSG00180052803	lncRNA gene	Chr11:92238719-92240048 (-)
C3H/HeJ	ENSMUSG00175052078	lncRNA gene	Chr11:92251164-92252455 (-)
C57BL/6NJ	ENSMUSG00215054327	lncRNA gene	Chr11:91843292-91844614 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005017249	lncRNA gene	Chr11:91700696-91702028 (-)
CBA/J	ENSMUSG00210053690	lncRNA gene	Chr11:91954562-91955853 (-)
DBA/2J	ENSMUSG00185051891	lncRNA gene	Chr11:92291995-92293314 (-)
FVB/NJ	ENSMUSG00205049840	lncRNA gene	Chr11:92157257-92158576 (-)
JF1/MsJ	ENSUMUG00000056530	lncRNA gene	Chr11:92606688-92607979 (-)
LP/J	ENSMUSG00230051459	lncRNA gene	Chr11:93353466-93354783 (-)
NOD/ShiLtJ	ENSMUSG00190051789	lncRNA gene	Chr11:92332499-92333826 (-)
NZO/HlLtJ	ENSMUSG00225053428	lncRNA gene	Chr11:95400178-95401506 (-)
PWK/PhJ	ENSLUMG00010033546	lncRNA gene	Chr11:92154948-92156237 (-)
SPRET/EiJ	ENSMSPG00010051321	lncRNA gene	Chr11:92635887-92637224 (-)
WSB/EiJ	ENSIUOG00005051785	lncRNA gene	Chr11:92102437-92103757 (-)

Homology

• Gene Tree
  Discn
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Gene trapped
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit postnatal lethality, increased anxiety-associated behaviors, increased grooming behavior, compromised long term memory, impaired coordination, and increased double strand breaks in the brain with increased immune reaction.

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  2

• Ensembl
  ENSMUSG00000119939 (Evidence)
• NCBI Gene
  102643127

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000119939	Ensembl Gene Model | MGI Sequence Detail	1600	C57BL/6J
transcript	ENSMUST00000240705	Ensembl | MGI Sequence Detail	866	Not Applicable

Other
Accession IDs

MGI:7526542

References

• Summaries
  All 6

  Phenotypes 3
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:340217 Wang L, et al., A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. Nat Commun. 2021 Sep 22;12(1):5572