Discn Gene Detail

Summary

• Symbol
  Discn
• Name
  DNA damage-induced stem cell specific noncoding RNA
• Synonyms
  Gm38659

• Feature Type
  lncRNA gene
• IDs
  MGI:5621544
  NCBI Gene: 102643127
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr11:95026941-95028259 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  70 from dbSNP Build 142
• Strain Annotations
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5621544	lncRNA gene	Chr11:95026941-95030764 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Gene Tree
  Discn
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Gene trapped
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit postnatal lethality, increased anxiety-associated behaviors, increased grooming behavior, compromised long term memory, impaired coordination, and increased double strand breaks in the brain with increased immune reaction.

Sequences &
Gene Models

• All Sequences
  7
• RefSeq
  2

• Ensembl
  ENSMUSG00000119939 (Evidence)
• NCBI Gene
  102643127

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000119939	Ensembl Gene Model | MGI Sequence Detail	1319	C57BL/6J
transcript	ENSMUST00000240705	Ensembl | MGI Sequence Detail	822	Not Applicable

References

• Summaries
  All 6

  Phenotypes 3
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:340217 Wang L, et al., A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. Nat Commun. 2021 Sep 22;12(1):5572