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Rubie Gene Detail
Summary
  • Symbol
    Rubie
  • Name
    RNA upstream of Bmp4 expressed in inner ear
  • Synonyms
    Gm15219
  • Feature Type
    lncRNA gene
  • IDs
    MGI:5568573
    NCBI Gene: 100873094
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:46805788-46813308 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.11 cM
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5568573
 lncRNA gene Chr14:46805720-46835882 (-)
129S1/SvImJ MGP_129S1SvImJ_G0005540
 lincRNA gene Chr14:40244449-40251181 (-)
A/J MGP_AJ_G0005526
 lincRNA gene Chr14:39047866-39054062 (-)
AKR/J MGP_AKRJ_G0005505
 lincRNA gene Chr14:40570250-40575776 (-)
BALB/cJ MGP_BALBcJ_G0005508
 lincRNA gene Chr14:39106701-39112186 (-)
C3H/HeJ MGP_C3HHeJ_G0005455
 lincRNA gene Chr14:40354700-40360876 (-)
C57BL/6NJ MGP_C57BL6NJ_G0005664
 lincRNA gene Chr14:41992937-41998483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0005033
 lincRNA gene Chr14:38430476-38436367 (-)
CAST/EiJ MGP_CASTEiJ_G0005397
 lincRNA gene Chr14:37479518-37486362 (-)
CBA/J MGP_CBAJ_G0005444
 lincRNA gene Chr14:43325654-43333665 (-)
DBA/2J MGP_DBA2J_G0005460
 lincRNA gene Chr14:38955866-38961519 (-)
FVB/NJ MGP_FVBNJ_G0005486
 lincRNA gene Chr14:38691990-38697599 (-)
LP/J MGP_LPJ_G0005544
 lincRNA gene Chr14:40542304-40548438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0005470
 lincRNA gene Chr14:42706714-42712871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0005663
 lincRNA gene Chr14:40113145-40120738 (-)
PWK/PhJ MGP_PWKPhJ_G0005348
 lincRNA gene Chr14:35824612-35830428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0005266
 lincRNA gene Chr14:36252608-36258105 (-)
WSB/EiJ MGP_WSBEiJ_G0005447
 lincRNA gene Chr14:40220814-40227573 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous retroviral insertion that is SWR-specific exhibit hyperactivity, bidirectional circling, and abnormal lateral semicircular canal formation. Mice homozygous for a null allele exhibit circling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    14
  • cDNA Data
    2
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      26
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100873094 NCBI Gene Model | MGI Sequence Detail 7521 C57BL/6J ±  kb
    transcript NR_046459 RefSeq | MGI Sequence Detail 1404 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 2
      Primer pair 8
    Other
    Accession IDs
    less
    MGI:3705294
    References
    more
    • Summaries
      All 9
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:209710 Roberts KA, et al., Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice. PLoS One. 2012;7(1):e29495
    • Latest
      J:284183 George MR, et al., Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 Dec 9;146(23):dev185314
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/23/2024
    MGI 6.23     		The Jackson Laboratory