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Tg(Ly6e-MALT1)#Isg
Transgene Detail
Summary
Symbol: Tg(Ly6e-MALT1)#Isg
Name: transgene insertion, Isidro Sanchez-Garcia
MGI ID: MGI:5432016
Synonyms: Sca1-MALT1
Transgene: Tg(Ly6e-MALT1)#Isg  Location: unknown  
Alliance: Tg(Ly6e-MALT1)#Isg page
Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas

Show the 7 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ly6e-MALT1)#Isg expresses 1 gene
 
Mutation detailsThe mouse Ly6a promoter drives expression of the human MALT1 gene in the hematopoietic stem/progenitor cell compartment. Three lines (86A, 86B, 86C) were generated with 2 - 4 copies of the transgene inserted. RT-PCR and western blot analysis confirmed that transgene expression is restricted to Sca1+Lin- cells. (J:185590)
Schematic of the Tg(Ly6e-MALT1)#Isg transgene
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:185590 Vicente-Duenas C, et al., Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10534-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory