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Malt1 Gene Detail
Summary
  • Symbol
    Malt1
  • Name
    MALT1 paracaspase
  • Synonyms
    D430033E09Rik, paracaspase, Pcasp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445027
    NCBI Gene: 240354
  • Alliance
  • Transcription Start Sites
    69 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65564010-65611959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 38.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445027
protein coding gene Chr18:65564009-65612138 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024508
protein coding gene Chr18:65564672-65614340 (+)
A/J MGP_AJ_G0024475
protein coding gene Chr18:62722762-62770569 (+)
AKR/J MGP_AKRJ_G0024445
protein coding gene Chr18:64493258-64540952 (+)
BALB/cJ MGP_BALBcJ_G0024474
protein coding gene Chr18:62862314-62910618 (+)
C3H/HeJ MGP_C3HHeJ_G0024242
protein coding gene Chr18:64687444-64740064 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024921
protein coding gene Chr18:67319113-67368314 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022352
protein coding gene Chr18:62158737-62208656 (+)
CAST/EiJ MGP_CASTEiJ_G0023715
protein coding gene Chr18:64663995-64715636 (+)
CBA/J MGP_CBAJ_G0024212
protein coding gene Chr18:69515140-69567768 (+)
DBA/2J MGP_DBA2J_G0024342
protein coding gene Chr18:62375699-62425608 (+)
FVB/NJ MGP_FVBNJ_G0024308
protein coding gene Chr18:61770247-61817998 (+)
LP/J MGP_LPJ_G0024426
protein coding gene Chr18:65419890-65471029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024337
protein coding gene Chr18:70944089-70996472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024968
protein coding gene Chr18:64702136-64750627 (+)
PWK/PhJ MGP_PWKPhJ_G0023458
protein coding gene Chr18:62631318-62680520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023263
protein coding gene Chr18:64849120-64899617 (+)
WSB/EiJ MGP_WSBEiJ_G0023779
protein coding gene Chr18:64554557-64604585 (+)



Homology
more
  • Human Ortholog
    MALT1, MALT1 paracaspase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MALT1, MALT1 paracaspase
  • Synonyms
    IMD12, MLT, MLT1, PCASP1
  • Links
    NCBI Gene ID: 10892
    neXtProt AC: NX_Q9UDY8
    UniProt: Q9UDY8

  • Chr Location
    18q21.32; chr18:58671465-58754477 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human MALT1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene disrupts normal B cell development and leads to impaired cytokine production and T cell and B cell proliferative responses after antigen receptor engagement due to failure of NF-kappaB activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240354 NCBI Gene Model | MGI Sequence Detail 47950 C57BL/6J ±  kb
    transcript NM_001365019 RefSeq | MGI Sequence Detail 5323 C57BL/6  
    polypeptide Q2TBA3 UniProt | EBI | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 58
    • Earliest
      J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
    • Latest
      J:337016 Wittner L, et al., Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int J Mol Sci. 2023 Apr 17;24(8)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/13/2024
    MGI 6.23
    The Jackson Laboratory