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Tmppe Gene Detail
Summary
  • Symbol
    Tmppe
  • Name
    transmembrane protein with metallophosphoesterase domain
Location &
Maps
more
  • Sequence Map
    Chr9:114230173-114236344 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.40 cM
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5317335
 protein coding gene Chr9:114230163-114240269 (+)
129S1/SvImJ ENSMUSG00200029696
 protein coding gene Chr9:111330600-111333355 (+)
A/J ENSMUSG00195032010
 protein coding gene Chr9:110535497-110538252 (+)
AKR/J ENSMUSG00220022973
 protein coding gene Chr9:110992797-110995552 (+)
BALB/cJ ENSMUSG00180025398
 protein coding gene Chr9:111073188-111075943 (+)
C3H/HeJ ENSMUSG00175016611
 protein coding gene Chr9:111294255-111297010 (+)
C57BL/6NJ ENSMUSG00215039643
 protein coding gene Chr9:111178555-111181310 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032769
 protein coding gene Chr9:109861944-109871308 (+)
CAST/EiJ ENSTCUG00005027782
 protein coding gene Chr9:110953769-110956528 (+)
CBA/J ENSMUSG00210030354
 protein coding gene Chr9:111015459-111018214 (+)
DBA/2J ENSMUSG00185014275
 protein coding gene Chr9:111352212-111354967 (+)
FVB/NJ ENSMUSG00205042447
 protein coding gene Chr9:111195938-111198693 (+)
JF1/MsJ ENSUMUG00000044389
 protein coding gene Chr9:111183015-111185776 (+)
LP/J ENSMUSG00230048539
 protein coding gene Chr9:111459368-111462123 (+)
NOD/ShiLtJ ENSMUSG00190047719
 protein coding gene Chr9:110945337-110948092 (+)
NZO/HlLtJ ENSMUSG00225023868
 protein coding gene Chr9:111740910-111743665 (+)
PWK/PhJ ENSLUMG00010029519
 protein coding gene Chr9:111133319-111136078 (+)
SPRET/EiJ ENSMSPG00010019769
 protein coding gene Chr9:112797908-112799709 (+)
WSB/EiJ ENSIUOG00005044849
 protein coding gene Chr9:110410831-110413586 (+)



Homology
more
  • Human Ortholog
    TMPPE, transmembrane protein with metallophosphoesterase domain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPPE, transmembrane protein with metallophosphoesterase domain
  • Links
    NCBI Gene ID: 643853
    UniProt: Q6ZT21

  • Chr Location
    3p22.3; chr3:33090421-33097146 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079260 Ensembl Gene Model | MGI Sequence Detail 6172 C57BL/6J ±  kb
transcript ENSMUST00000111820 Ensembl | MGI Sequence Detail 2921 Not Applicable  
polypeptide ENSMUSP00000107451 Ensembl | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR004843 Calcineurin-like, phosphoesterase domain
    IPR029052 Metallo-dependent phosphatase-like
    IPR051158 Metallophosphoesterase-like
  • GlyGen
    D3Z286 1 site
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3
References
more
  • Summaries
    All 13
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:23000 MGD Nomenclature Committee, Nomenclature Committee Use. 1995-02-14;
  • Latest
    J:389486 Mouse Genome Informatics and Ensembl Genome Database Project, MGI Strain Genome Feature and Gene Model Load from Ensembl. Database Release. 2026;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory