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Nme1nme2 Gene Detail
Summary
  • Symbol
    Nme1nme2
  • Name
    NME/NM23 nucleoside diphosphate kinase 1 and 2 readthrough
  • Synonyms
    Gm20390
  • Feature Type
    protein coding gene
  • IDs
    MGI:5141855
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:93840645-93859119 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.88 cM
Strain
Comparison
more
  • SNPs within 2kb
    638 from dbSNP Build 142
  • Strain Annotations
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5141855
 protein coding gene Chr11:93840645-93859119 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0016971
 protein coding gene Chr11:89670835-89689516 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
  • All Sequences
    6
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091228 Ensembl Gene Model | MGI Sequence Detail 18475 C57BL/6J ±  kb
transcript ENSMUST00000170303 Ensembl | MGI Sequence Detail 991 Not Applicable  
polypeptide ENSMUSP00000132590 Ensembl | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    2.7.4.6
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR023005 Nucleoside diphosphate kinase, active site
    IPR034907 Nucleoside diphosphate kinase-like domain
    IPR036850 Nucleoside diphosphate kinase-like domain superfamily
Other
Accession IDs
less
MGI:7516361
References
more
  • Summaries
    All 13
    Diseases 1
    Phenotypes 9
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:316091 Leonard MK, et al., Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Oncogene. 2021 Nov;40(45):6329-6342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory