Mir378b Gene Detail

Summary

• Symbol
  Mir378b
• Name
  microRNA 378b
• Synonyms
  mmu-mir-378b

• Feature Type
  miRNA gene
• IDs
  MGI:4950393
  NCBI Gene: 100628571
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr11:88243599-88243690 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 52.40 cM

Strain
Comparison

• SNPs within 2kb
  53 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4950393	miRNA gene	Chr11:88243599-88243690 (+)
129S1/SvImJ	ENSMUSG00200020791	miRNA gene	Chr11:85387160-85387251 (+)
A/J	ENSMUSG00195009722	miRNA gene	Chr11:85242083-85242174 (+)
AKR/J	ENSMUSG00220012309	miRNA gene	Chr11:85441803-85441894 (+)
BALB/cJ	ENSMUSG00180011737	miRNA gene	Chr11:85448160-85448251 (+)
C3H/HeJ	ENSMUSG00175033918	miRNA gene	Chr11:85388636-85388727 (+)
C57BL/6NJ	ENSMUSG00215032605	miRNA gene	Chr11:85019826-85019917 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007152	miRNA gene	Chr11:83590433-83590524 (+)
CAST/EiJ	ENSTCUG00005017114	miRNA gene	Chr11:84943094-84943185 (+)
CBA/J	ENSMUSG00210042098	miRNA gene	Chr11:85206179-85206270 (+)
DBA/2J	ENSMUSG00185020508	miRNA gene	Chr11:85522941-85523032 (+)
FVB/NJ	ENSMUSG00205021846	miRNA gene	Chr11:85401880-85401971 (+)
JF1/MsJ	ENSUMUG00000030820	miRNA gene	Chr11:85844549-85844640 (+)
LP/J	ENSMUSG00230030740	miRNA gene	Chr11:86556104-86556195 (+)
NOD/ShiLtJ	ENSMUSG00190020239	miRNA gene	Chr11:85554175-85554266 (+)
NZO/HlLtJ	ENSMUSG00225039914	miRNA gene	Chr11:88670755-88670846 (+)
PWK/PhJ	ENSLUMG00010035863	miRNA gene	Chr11:85393641-85393732 (+)
SPRET/EiJ	ENSMSPG00010029086	miRNA gene	Chr11:85802402-85802493 (+)
WSB/EiJ	ENSIUOG00005008555	miRNA gene	Chr11:85367730-85367821 (+)

Homology

• Gene Tree
  Mir378b
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  10 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  4 involving Mir378b
• Find Mice (IMSR)
  0 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Females with a null allele are unable to clear Chlamydia infection and have higher bacterial burden during infection, however mice show reduced uterine pathology, protection from Chlamydia-induced infertility, and reduced proinflammatory immune response following infection.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  597

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  24
• RefSeq
  1

• Ensembl
  ENSMUSG00000092985 (Evidence)
• NCBI Gene
  100628571

Representative Sequences			Length	Strain/Species
genomic	100628571	NCBI Gene Model | MGI Sequence Detail	92	C57BL/6J
transcript	NR_039545	RefSeq | MGI Sequence Detail	92	ZRU/MplStud

Other Database
Links

miRBase

MI0016973

References

• Summaries
  All 16

  Diseases 1

  Gene Ontology 1

  Phenotypes 10
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:307588 Lundy SR, et al., MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology. Pathogens. 2021 May 7;10(5)