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Ighv5-6 Gene Detail
Summary
  • Symbol
    Ighv5-6
  • Name
    immunoglobulin heavy variable 5-6
  • Synonyms
    Gm16891
  • Feature Type
    gene segment
  • IDs
    MGI:4439815
    NCBI Gene: 777780
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113589128-113589421 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4439815
gene segment Chr12:113589126-113589576 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0000045
gene segment Chr12:115684643-115685102 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000057
gene segment Chr12:119715371-119715830 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0000046
gene segment Chr12:111181936-111305725 (-)
FVB/NJ MGP_FVBNJ_G0000042
gene segment Chr12:110018687-110019146 (-)
LP/J MGP_LPJ_G0000049
gene segment Chr12:116249426-116250012 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000045
gene segment Chr12:127405133-127405592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000058
gene segment Chr12:114580643-114581102 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0000048
gene segment Chr12:115580747-115581206 (+)



Homology
more
  • Human Ortholog
    IGHV3-13, immunoglobulin heavy variable 3-13
  • Vertebrate Orthologs
    20
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHV3-13, immunoglobulin heavy variable 3-13
  • Synonyms
    IGHV313
  • Links
    NCBI Gene ID: 28449
    UniProt: P01766

  • Chr Location
    14q32.33; chr14:106129540-106130072 (-)  GRCh38

  • Human Ortholog
    IGHV3-20, immunoglobulin heavy variable 3-20
  • Synonyms
    IGHV320, VH
  • Links
    NCBI Gene ID: 28445
    UniProt: A0A0C4DH32

  • Chr Location
    14q32.33; chr14:106210936-106211453 (-)  GRCh38

  • Human Ortholog
    IGHV3-23, immunoglobulin heavy variable 3-23
  • Synonyms
    DP47, IGHV323, V3-23, VH26
  • Links
    NCBI Gene ID: 28442
    UniProt: P01764

  • Chr Location
    14q32.33; chr14:106268606-106269140 (-)  GRCh38

  • Human Ortholog
    IGHV3-30, immunoglobulin heavy variable 3-30
  • Synonyms
    IGHV330, VH
  • Links
    NCBI Gene ID: 28439
    UniProt: P01768

  • Chr Location
    14q32.33; chr14:106335080-106335613 (-)  GRCh38

  • Human Ortholog
    IGHV3-30-3, immunoglobulin heavy variable 3-30-3
  • Synonyms
    IGHV3-3, IGHV3303
  • Links
    NCBI Gene ID: 57290
    UniProt: P0DP02

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV3-30-5, immunoglobulin heavy variable 3-30-5
  • Synonyms
    IGHV3-3, IGHV3305
  • Links
    NCBI Gene ID: 89770
    UniProt: P0DP03

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV3-33, immunoglobulin heavy variable 3-33
  • Synonyms
    IGHV333, VH
  • Links
    NCBI Gene ID: 28434
    UniProt: P01772

  • Chr Location
    14q32.33; chr14:106359791-106360324 (-)  GRCh38

  • Human Ortholog
    IGHV3-35, immunoglobulin heavy variable 3-35 (non-functional)
  • Synonyms
    IGHV335, VH
  • Links
    NCBI Gene ID: 28432
    UniProt: A0A0C4DH35

  • Chr Location
    14q32.33; chr14:106389390-106389858 (-)  GRCh38

  • Human Ortholog
    IGHV3-38, immunoglobulin heavy variable 3-38 (non-functional)
  • Synonyms
    IGHV338, VH
  • Links
    NCBI Gene ID: 28429
    UniProt: A0A0C4DH36

  • Chr Location
    14q32.33; chr14:106410493-106411021 (-)  GRCh38

  • Human Ortholog
    IGHV3-38-3, immunoglobulin heavy variable 3-38-3 (non-functional)
  • Synonyms
    IGH, IGHV3D, IGHV3-D
  • Links
    NCBI Gene ID: 28404
    UniProt: P0DTE1

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV3-43, immunoglobulin heavy variable 3-43
  • Synonyms
    IGHV343, VH
  • Links
    NCBI Gene ID: 28426
    UniProt: A0A0B4J1X8

  • Chr Location
    14q32.33; chr14:106470263-106470800 (-)  GRCh38

  • Human Ortholog
    IGHV3-53, immunoglobulin heavy variable 3-53
  • Synonyms
    IGHV353, VH
  • Links
    NCBI Gene ID: 28420
    UniProt: P01767

  • Chr Location
    14q32.33; chr14:106592676-106593347 (-)  GRCh38

  • Human Ortholog
    IGHV3-64, immunoglobulin heavy variable 3-64
  • Synonyms
    IGHV364, VH
  • Links
    NCBI Gene ID: 28414
    UniProt: A0A075B6Q5

  • Chr Location
    14q32.33; chr14:106657723-106658258 (-)  GRCh38

  • Human Ortholog
    IGHV3-64D, immunoglobulin heavy variable 3-64D
  • Links
    NCBI Gene ID: 102723170
    UniProt: A0A0J9YX35

  • Chr Location
    14q32.33; chr14:106088122-106088573 (-)  GRCh38

  • Human Ortholog
    IGHV3-66, immunoglobulin heavy variable 3-66
  • Synonyms
    IGHV366, VH
  • Links
    NCBI Gene ID: 28412
    UniProt: A0A0C4DH42

  • Chr Location
    14q32.33; chr14:106675015-106675544 (-)  GRCh38

  • Human Ortholog
    IGHV3-74, immunoglobulin heavy variable 3-74
  • Synonyms
    IGHV374, VH
  • Links
    NCBI Gene ID: 28408
    UniProt: A0A0B4J1X5

  • Chr Location
    14q32.33; chr14:106810440-106811131 (-)  GRCh38

  • Human Ortholog
    IGHV3-9, immunoglobulin heavy variable 3-9
  • Synonyms
    IGHV39, VH
  • Links
    NCBI Gene ID: 28451
    UniProt: P01782

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV3OR16-10, immunoglobulin heavy variable 3/OR16-10 (non-functional)
  • Synonyms
    IGHV3OR1610
  • Links
    NCBI Gene ID: 28306

  • Chr Location
    16p11.2; chr16:32995048-32995505 (+)  GRCh38

  • Human Ortholog
    IGHV3OR16-8, immunoglobulin heavy variable 3/OR16-8 (non-functional)
  • Synonyms
    IGHV3OR168, IGHV3/OR16-8
  • Links
    NCBI Gene ID: 388255

  • Chr Location
    16p11.2; chr16:33009124-33009646 (+)  GRCh38

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic 777780 NCBI Gene Model | MGI Sequence Detail 294 C57BL/6J ±  kb
polypeptide A0A075B5Q0 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
References
more
  • Summaries
    All 7
    Gene Ontology 1
  • Earliest
    J:61333 Langdon SD, et al., Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. Immunogenetics. 2000 Mar;51(3):241-5
  • Latest
    J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory