Traj33 Gene Detail

Summary

• Symbol
  Traj33
• Name
  T cell receptor alpha joining 33
• Synonyms
  Gm16666

• Feature Type
  gene segment
• IDs
  MGI:4439590
  NCBI Gene: 100124356
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr14:54422815-54422871 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 27.68 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  51 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439590	gene segment	Chr14:54422815-54422871 (+)
129S1/SvImJ	ENSMUSG00200044435	gene segment	Chr14:43015093-43015149 (+)
A/J	ENSMUSG00195034941	gene segment	Chr14:43239361-43239417 (+)
AKR/J	ENSMUSG00220036281	gene segment	Chr14:42567297-42567353 (+)
BALB/cJ	ENSMUSG00180053131	gene segment	Chr14:42863130-42863186 (+)
C3H/HeJ	ENSMUSG00175051514	gene segment	Chr14:44545572-44545628 (+)
C57BL/6NJ	ENSMUSG00215050943	gene segment	Chr14:42745111-42745167 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002151	gene segment	Chr14:45618477-45618533 (+)
CAST/EiJ	ENSTCUG00005048891	gene segment	Chr14:44541819-44541875 (+)
CBA/J	ENSMUSG00210048405	gene segment	Chr14:43226131-43226187 (+)
DBA/2J	ENSMUSG00185056219	gene segment	Chr14:48266784-48266840 (+)
FVB/NJ	ENSMUSG00205045303	gene segment	Chr14:42609049-42609105 (+)
JF1/MsJ	ENSUMUG00000055620	gene segment	Chr14:59525340-59525396 (+)
LP/J	ENSMUSG00230052884	gene segment	Chr14:60381088-60381144 (+)
NOD/ShiLtJ	ENSMUSG00190051753	gene segment	Chr14:42969867-42969923 (+)
NZO/HlLtJ	ENSMUSG00225051623	gene segment	Chr14:50679178-50679234 (+)
PWK/PhJ	ENSLUMG00010050539	gene segment	Chr14:42449189-42449245 (+)
SPRET/EiJ	ENSMSPG00010046318	gene segment	Chr14:45839993-45840049 (+)
WSB/EiJ	ENSIUOG00005046646	gene segment	Chr14:42440878-42440934 (+)

Homology

• Human Ortholog
  TRAJ33, T cell receptor alpha joining 33

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRAJ33, T cell receptor alpha joining 33
  
• Links
  HGNC:12063

  NCBI Gene ID: 28722

  
  
• Chr Location
  14q11.2; chr14:22508602-22508658 (+)  GRCh38

---

• MGI Vertebrate Homology
  Traj33 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: TRAJ33
• Gene Tree
  Traj33
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  3 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  3 involving Traj33
• Find Mice (IMSR)
  2 strains or lines available

Mcie homozygous for a knock-out allele exhibit reduced mucosal-associated invariant T cells.

Expression

• Assay Results
  597

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000076896 (Evidence)
• NCBI Gene
  100124356

Representative Sequences			Length	Strain/Species
genomic	100124356	NCBI Gene Model | MGI Sequence Detail	57	C57BL/6J
polypeptide	A0A0G2JDY8	UniProt | EBI | MGI Sequence Detail	19	Not Applicable

Protein
Information

• UniProt
  1 Sequence

References

• Summaries
  All 21

  Phenotypes 3
• Earliest
  J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
• Latest
  J:390108 Loh L, et al., MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Mucosal Immunol. 2025 Aug;18(4):958-972