Methig1 Gene Detail

Summary

• Symbol
  Methig1
• Name
  methyltransferase hypoxia inducible domain containing 1
• Synonyms
  AB099516, Mettl7a2-Higd1c, Mettl7a2Higd1c, UbiE2-Hig1-4, UbiE-YGHL1

• Feature Type
  protein coding gene
• IDs
  MGI:3845761
  NCBI Gene: 554292
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr15:100251081-100282316 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.27 cM

Strain
Comparison

• SNPs within 2kb
  1077 from dbSNP Build 142
• Strain Annotations
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3845761	protein coding gene	Chr15:100251030-100282317 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0020285	protein coding gene	Chr15:94046998-94048054 (+)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
JF1/MsJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Gene Tree
  Methig1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Radiation induced
  2
• Genomic Mutations
  3 involving Methig1
• Find Mice (IMSR)
  9 strains or lines available

Expression

• Assay Results
  597
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  22
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS27835.1

• Ensembl
  ENSMUSG00000093789 (Evidence)
• NCBI Gene
  554292

Representative Sequences			Length	Strain/Species
genomic	554292	NCBI Gene Model | MGI Sequence Detail	31236	C57BL/6J
transcript	NM_001024672	RefSeq | MGI Sequence Detail	1449	C57BL/6
polypeptide	NP_001019843	RefSeq | MGI Sequence Detail	264	C57BL/6

Protein
Information

• UniProt
  4 Sequences
• InterPro Domains
  IPR007667 Hypoxia induced protein, domain
  IPR013216 Methyltransferase type 11
  IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
  IPR052356 Thiol S-methyltransferase

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 1

References

• Summaries
  All 32

  Diseases 1

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)