Altre Gene Detail

Summary

• Symbol
  Altre
• Name
  aging liver Treg-expressed non-protein coding RNA
• Synonyms
  Gm16157

• Feature Type
  lncRNA gene
• IDs
  MGI:3801721
  NCBI Gene: 100504026
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr7:67916087-67926342 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 37.49 cM

Strain
Comparison

• SNPs within 2kb
  391 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3801721	lncRNA gene	Chr7:67915783-67930487 (-)
129S1/SvImJ	ENSMUSG00200012084	lncRNA gene	Chr7:54630661-54640930 (-)
A/J	ENSMUSG00195013123	lncRNA gene	Chr7:59055190-59065462 (-)
AKR/J	ENSMUSG00220020408	lncRNA gene	Chr7:52555989-52566259 (-)
BALB/cJ	ENSMUSG00180004726	lncRNA gene	Chr7:55765140-55775407 (-)
C3H/HeJ	ENSMUSG00175011220	lncRNA gene	Chr7:56557628-56567898 (-)
C57BL/6NJ	ENSMUSG00215025547	lncRNA gene	Chr7:55693321-55703577 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0006542	lincRNA gene	Chr7:70968380-70978760 (-)
CAST/EiJ	ENSTCUG00005012120	lncRNA gene	Chr7:59236319-59246801 (-)
CBA/J	ENSMUSG00210019870	lncRNA gene	Chr7:56396085-56406352 (-)
DBA/2J	ENSMUSG00185001093	lncRNA gene	Chr7:60731903-60742164 (-)
FVB/NJ	ENSMUSG00205004703	lncRNA gene	Chr7:56391142-56401405 (-)
JF1/MsJ	ENSUMUG00000011495	lncRNA gene	Chr7:65454261-65464865 (-)
LP/J	ENSMUSG00230021593	lncRNA gene	Chr7:66813751-66824012 (-)
NOD/ShiLtJ	ENSMUSG00190007521	lncRNA gene	Chr7:56504377-56514646 (-)
NZO/HlLtJ	ENSMUSG00225017366	lncRNA gene	Chr7:65094539-65104809 (-)
PWK/PhJ	ENSLUMG00010019697	lncRNA gene	Chr7:55012696-55023322 (-)
SPRET/EiJ	ENSMSPG00010003627	lncRNA gene	Chr7:55378990-55389659 (-)
WSB/EiJ	ENSIUOG00005005225	lncRNA gene	Chr7:56953062-56963323 (-)

Homology

• Gene Tree
  Altre
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  20
• Chemically induced (other)
  1
• Gene trapped
  17
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  2 involving Altre
• Find Mice (IMSR)
  15 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Aged male mice with loss of expression in regulatory T cells display reduced survival, increased liver tumor incidence and regulatory T cell abnormalities.

Expression

• Assay Results
  597
• cDNA Data
  5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  64
• RefSeq
  2

• Ensembl
  ENSMUSG00000086628 (Evidence)
• NCBI Gene
  100504026

Representative Sequences			Length	Strain/Species
genomic	100504026	NCBI Gene Model | MGI Sequence Detail	10256	C57BL/6J
transcript	NR_040340	RefSeq | MGI Sequence Detail	1147	ZRU/MplStud

Molecular
Reagents

• All nucleic 5

  cDNA 5

Other
Accession IDs

MGI:7444229

References

• Summaries
  All 21

  Phenotypes 13
• Earliest
  J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
• Latest
  J:342907 Ding C, et al., A T(reg)-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver. Nat Aging. 2023 Jul;3(7):813-828

TSS for Altre:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72877	Chr7:67926807-67926850 (-)	-487 bp
Tssr72876	Chr7:67926001-67926012 (-)	335 bp
Tssr72875	Chr7:67924855-67924868 (-)	1,480 bp