Mirc1 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc1
• Name
  microRNA cluster 1, including Mir17 through Mir92-1
• Synonyms
  miR-17~92, miR-17-92, Mir17-92, Mirn17-92

• Feature Type
  complex/cluster/region
• IDs
  MGI:3790484
• Cluster Members
  Mir17, Mir18, Mir19a ... (6 members)

Location &
Maps

• Sequence Map
  Chr14:115281103-115281938 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  5 from dbSNP Build 142

Human Diseases

• Diseases
  1 with Mirc1 mouse models

Human Disease

Mouse Models

Feingold syndrome

IDs

Feingold syndrome      

DOID:0060464
ICD10CM:Q87.8
MESH:C537734
OMIM:164280
OMIM:614326
ORDO:1305

View 1 model

Mouse Models

Human Disease Modeled: Feingold syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Mirc1tm1.2Tyj/Mirc1+	involves: 129S4/SvJae * C57BL/6	J:188762	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  44 phenotypes from 9 alleles in 12 genetic backgrounds
  28 phenotypes from multigenic genotypes
  74 phenotype references
  

• All Mutations and Alleles
  10
• Targeted
  9
• Transgenic
  1
• Find Mice (IMSR)
  6 strains or lines available

Homozygous deletion of this Mirn cluster results in neonatal lethality. Lung hypoplasia is observed in late gestation and newborn mice; fetal and adult B cell development are compromised also.

Expression

• Literature Summary
  4

Other Database
Links

miRBase

MI0000567, MI0000568, MI0000687, MI0000688, MI0000718, MI0000719

References

• Summaries
  All 86

  Developmental Gene Expression 4

  Diseases 1

  Phenotypes 74
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:337608 Dolz M, et al., Forced expression of the non-coding RNA miR-17 approximately 92 restores activation and function in CD28-deficient CD4(+) T cells. iScience. 2022 Nov 18;25(11):105372

Mirc1 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir17, microRNA 17	miRNA gene	Chr14:115281103-115281186 (+)
Mir18, microRNA 18	miRNA gene	Chr14:115281283-115281378 (+)
Mir19a, microRNA 19a	miRNA gene	Chr14:115281432-115281513 (+)
Mir20a, microRNA 20a	miRNA gene	Chr14:115281589-115281695 (+)
Mir19b-1, microRNA 19b-1	miRNA gene	Chr14:115281737-115281823 (+)
Mir92-1, microRNA 92-1	miRNA gene	Chr14:115281859-115281938 (+)