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Kcnj13 Gene Detail
Summary
  • Symbol
    Kcnj13
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 13
  • Feature Type
    protein coding gene
  • IDs
    MGI:3781032
    NCBI Gene: 100040591
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87314085-87322451 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3781032
 protein coding gene Chr1:87309133-87322451 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016264
 protein coding gene Chr1:88739900-88748251 (-)
A/J MGP_AJ_G0016245
 protein coding gene Chr1:85423788-85432139 (-)
AKR/J MGP_AKRJ_G0016206
 protein coding gene Chr1:87939265-87947631 (-)
BALB/cJ MGP_BALBcJ_G0016202
 protein coding gene Chr1:85541733-85550099 (-)
C3H/HeJ MGP_C3HHeJ_G0016030
 protein coding gene Chr1:88198933-88207284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016658
 protein coding gene Chr1:92062943-92071309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014380
 protein coding gene Chr1:79872682-79881051 (-)
CAST/EiJ MGP_CASTEiJ_G0015615
 protein coding gene Chr1:87422694-87430995 (-)
CBA/J MGP_CBAJ_G0016006
 protein coding gene Chr1:94974034-94982400 (-)
DBA/2J MGP_DBA2J_G0016109
 protein coding gene Chr1:84724759-84733110 (-)
FVB/NJ MGP_FVBNJ_G0016108
 protein coding gene Chr1:83785298-83793649 (-)
LP/J MGP_LPJ_G0016180
 protein coding gene Chr1:89812246-89820597 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016134
 protein coding gene Chr1:98248177-98256546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016701
 protein coding gene Chr1:88056428-88064779 (-)
PWK/PhJ MGP_PWKPhJ_G0015402
 protein coding gene Chr1:84023524-84031907 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015182
 protein coding gene Chr1:86974205-86982501 (-)
WSB/EiJ MGP_WSBEiJ_G0015679
 protein coding gene Chr1:87725745-87734110 (-)



Homology
more
  • Human Ortholog
    KCNJ13, potassium inwardly rectifying channel subfamily J member 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ13, potassium inwardly rectifying channel subfamily J member 13
  • Synonyms
    KIR1.4, KIR7.1, LCA16, SVD
  • Links
    NCBI Gene ID: 3769
    neXtProt AC: NX_O60928
    UniProt: O60928

  • Chr Location
    2q37.1; chr2:232765802-232776565 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNJ13 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant null mice die shortly after birth, exhibit cleft palate and pulmonary abnormalities in embryonic lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    26
  • cDNA Data
    3
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079436 Ensembl Gene Model | MGI Sequence Detail 8367 C57BL/6J ±  kb
    transcript ENSMUST00000113212 Ensembl | MGI Sequence Detail 1270 Not Applicable  
    polypeptide ENSMUSP00000108838 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000002054 inward rectifier potassium channel 13
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR008062 Inward rectifier potassium channel 13
      IPR041647 Inward rectifier potassium channel, C-terminal
      IPR016449 Potassium channel, inwardly rectifying, Kir
      IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
      IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:319656 Jiao X, et al., Retinal Development and Pathophysiology in Kcnj13 Knockout Mice. Front Cell Dev Biol. 2021;9:810020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory