Ces1b MGI Mouse Gene Detail - MGI:3779470

Symbol

Ces1b
Name

carboxylesterase 1B
Synonyms

Gm5158

Feature Type

protein coding gene
IDs

MGI:3779470
NCBI Gene: 382044
Member of

Ces1 cluster
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:93783356-93806645 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 44.99 cM
Mapping Data

1 experiment

SNPs within 2kb

1200 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3779470	protein coding gene	Chr8:93783353-93806645 (-)
129S1/SvImJ	ENSMUSG00200016745	protein coding gene	Chr8:88142841-88166203 (-)
A/J	ENSMUSG00195026073	protein coding gene	Chr8:88511128-88534500 (-)
AKR/J	ENSMUSG00220037190	protein coding gene	Chr8:88513969-88537335 (-)
BALB/cJ	ENSMUSG00180019081	protein coding gene	Chr8:88339380-88362748 (-)
C3H/HeJ	ENSMUSG00175024062	protein coding gene	Chr8:88449313-88472679 (-)
C57BL/6NJ	ENSMUSG00215014679	protein coding gene	Chr8:88053646-88076926 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031378	protein coding gene	Chr8:84582961-84610868 (-)
CAST/EiJ	ENSTCUG00005016561	protein coding gene	Chr8:87921218-87945086 (-)
CBA/J	ENSMUSG00210029292	protein coding gene	Chr8:88388948-88412314 (-)
DBA/2J	ENSMUSG00185023085	protein coding gene	Chr8:94497703-94521069 (-)
FVB/NJ	ENSMUSG00205014443	protein coding gene	Chr8:87468903-87492269 (-)
JF1/MsJ	ENSUMUG00000019138	protein coding gene	Chr8:96851527-96874895 (-)
LP/J	ENSMUSG00230028339	protein coding gene	Chr8:98136633-98159993 (-)
NOD/ShiLtJ	ENSMUSG00190013713	protein coding gene	Chr8:88491665-88515070 (-)
NZO/HlLtJ	ENSMUSG00225009543	protein coding gene	Chr8:101538451-101561819 (-)
PWK/PhJ	ENSLUMG00010034362	protein coding gene	Chr8:88181240-88204481 (-)
SPRET/EiJ	ENSMSPG00010026341	protein coding gene	Chr8:90161748-90191574 (-)
WSB/EiJ	ENSIUOG00005017421	protein coding gene	Chr8:89222837-89246211 (-)

Human Ortholog

CES1, carboxylesterase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CES1, carboxylesterase 1
Synonyms

ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
Links

HGNC:1863

NCBI Gene ID: 1066

UniProt: P23141
Chr Location

16q12.2; chr16:55802845-55833337 (-) GRCh38

Human Ortholog

CES1P1, carboxylesterase 1 pseudogene 1
Synonyms

CES1A2, CES1A3, CES4, CESR, PCE-3
Links

HGNC:18546

NCBI Gene ID: 51716
Chr Location

16q12.2; chr16:55760460-55794158 (+) GRCh38

MGI Vertebrate Homology

Ces1b stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CES1, CES1P1
Gene Tree

Ces1b

Diseases

2 with human CES1 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				gastrointestinal system cancer IDs gastrointestinal system cancer DOID:3119 DOID:4945 DOID:8377 ICD10CM:C26.9 ICD9CM:239.0 MESH:D004067 MESH:D005770 NCI:C3052 NCI:C4890 UMLS_CUI:C0012243 UMLS_CUI:C0017185 UMLS_CUI:C0685938

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS40431.1

Ensembl

ENSMUSG00000078964 (Evidence)
NCBI Gene

382044

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078964	Ensembl Gene Model \| MGI Sequence Detail	23290	C57BL/6J	± kb
transcript	ENSMUST00000109582	Ensembl \| MGI Sequence Detail	1964	Not Applicable
polypeptide	ENSMUSP00000105210	Ensembl \| MGI Sequence Detail	567	Not Applicable

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UniProt

1 Sequence
EC

3.1.1.-
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR002018 Carboxylesterase, type B

IPR019826 Carboxylesterase type B, active site

IPR019819 Carboxylesterase type B, conserved site

IPR050309 Type-B Carboxylesterase/Lipase
GlyGen

D3Z5G7 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 22

Gene Ontology 6

Phenotypes 5
Earliest

J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
Latest

J:267654 Saul MC, et al., Genomic variants in an inbred mouse model predict mania-like behaviors. PLoS One. 2018;13(5):e0197624

TSS for Ces1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82438	Chr8:93806593-93806602 (-)	47 bp
Tssr82437	Chr8:93806564-93806574 (-)	76 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24