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Bend2 Gene Detail
Summary
  • Symbol
    Bend2
  • Name
    BEN domain containing 2
  • Synonyms
    Gm15262
Location &
Maps
more
  • Sequence Map
    ChrX:160080852-160124208 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.95 cM
Strain
Comparison
more
  • SNPs within 2kb
    846 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3705232
 protein coding gene ChrX:160070452-160149248 (+)
129S1/SvImJ ENSMUSG00200024675
 protein coding gene ChrX:136792733-136871529 (+)
A/J ENSMUSG00195037708
 protein coding gene ChrX:141917902-141996940 (+)
AKR/J ENSMUSG00220027097
 protein coding gene ChrX:133773742-133852542 (+)
BALB/cJ ENSMUSG00180038228
 protein coding gene ChrX:137291351-137370182 (+)
C3H/HeJ ENSMUSG00175024859
 protein coding gene ChrX:141860677-141939484 (+)
C57BL/6NJ ENSMUSG00215016122
 protein coding gene ChrX:137687555-137766361 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005032142
 protein coding gene ChrX:139445895-139519808 (+)
CBA/J ENSMUSG00210036558
 protein coding gene ChrX:139177898-139256692 (+)
DBA/2J ENSMUSG00185030000
 protein coding gene ChrX:154124152-154202953 (+)
FVB/NJ ENSMUSG00205029096
 protein coding gene ChrX:137792182-137870989 (+)
JF1/MsJ ENSUMUG00000023301
 protein coding gene ChrX:174512313-174588413 (+)
LP/J ENSMUSG00230012204
 protein coding gene ChrX:160913612-160992410 (+)
NOD/ShiLtJ ENSMUSG00190029240
 protein coding gene ChrX:138294030-138372859 (+)
NZO/HlLtJ ENSMUSG00225037848
 protein coding gene ChrX:164302775-164381602 (+)
PWK/PhJ ENSLUMG00010037294
 protein coding gene ChrX:135608127-135684175 (+)
SPRET/EiJ ENSMSPG00010017598
 protein coding gene ChrX:140692551-140775697 (+)
WSB/EiJ ENSIUOG00005024475
 protein coding gene ChrX:138571426-138650269 (+)



Homology
more
  • Human Ortholog
    BEND2, BEN domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BEND2, BEN domain containing 2
  • Synonyms
    CXorf20
  • Links
    NCBI Gene ID: 139105
    UniProt: Q8NDZ0

  • Chr Location
    Xp22.13; chrX:18162931-18220886 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility due to azoospermia and increased male germ cell apoptosis with male meiosis arrest at the transition from zygonema to pachynema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      41
    • RefSeq
      2
    • UniProt
      6
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108168453 NCBI Gene Model | MGI Sequence Detail 43357 C57BL/6J ±  kb
    transcript XM_036162140 RefSeq | MGI Sequence Detail 1362 C57BL/6J  
    polypeptide A0A140LIQ5 UniProt | EBI | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Other
    Accession IDs
    less
    MGI:7284683
    References
    more
    • Summaries
      All 14
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:46359 Blair HJ, et al., Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. Hum Mol Genet. 1998 Mar;7(3):549-55
    • Latest
      J:377203 Shi Y, et al., Oncogenic fusions converge on shared mechanisms in initiating astroblastoma. Nature. 2025 Jul;643(8071):551-561
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory