Hotairm1 Gene Detail

Summary

• Symbol
  Hotairm1
• Name
  Hoxa transcript antisense RNA, myeloid-specific 1
• Synonyms
  Gm15051, Hoxaas1

• Feature Type
  antisense lncRNA gene
  BioType Conflict
  
• IDs
  MGI:3705155
  NCBI Gene: 105242658
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr6:52135504-52139000 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 25.40 cM

Strain
Comparison

• SNPs within 2kb
  71 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3705155	antisense lncRNA gene	Chr6:52133896-52139284 (+)
129S1/SvImJ	ENSMUSG00200005480	lncRNA gene	Chr6:49111202-49116419 (+)
A/J	ENSMUSG00195007045	lncRNA gene	Chr6:48835078-48840305 (+)
AKR/J	ENSMUSG00220004480	lncRNA gene	Chr6:48544190-48549408 (+)
BALB/cJ	ENSMUSG00180025397	lncRNA gene	Chr6:49136797-49142024 (+)
C3H/HeJ	ENSMUSG00175018223	lncRNA gene	Chr6:48903359-48908582 (+)
C57BL/6NJ	ENSMUSG00215011278	lncRNA gene	Chr6:49087650-49092867 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003856	antisense lncRNA gene	Chr6:46640457-46645740 (+)
CAST/EiJ	ENSTCUG00005005112	lncRNA gene	Chr6:48393652-48398917 (+)
CBA/J	ENSMUSG00210018506	lncRNA gene	Chr6:48947656-48952880 (+)
DBA/2J	ENSMUSG00185013934	lncRNA gene	Chr6:49529909-49535132 (+)
FVB/NJ	ENSMUSG00205030824	lncRNA gene	Chr6:49188034-49193259 (+)
JF1/MsJ	ENSUMUG00000015689	lncRNA gene	Chr6:48902513-48907787 (+)
LP/J	ENSMUSG00230019555	lncRNA gene	Chr6:50608507-50613724 (+)
NOD/ShiLtJ	ENSMUSG00190036414	lncRNA gene	Chr6:48865065-48870270 (+)
NZO/HlLtJ	ENSMUSG00225013587	lncRNA gene	Chr6:52592447-52597672 (+)
PWK/PhJ	ENSLUMG00010021087	lncRNA gene	Chr6:48639534-48644805 (+)
SPRET/EiJ	ENSMSPG00010010344	lncRNA gene	Chr6:49223494-49228735 (+)
WSB/EiJ	ENSIUOG00005028863	lncRNA gene	Chr6:49210539-49215739 (+)

Homology

• Human Ortholog
  HOTAIRM1, HOXA transcript antisense RNA, myeloid-specific 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  HOTAIRM1, HOXA transcript antisense RNA, myeloid-specific 1
  
• Synonyms
  HOXA1-AS1, HOXA-AS1, NCRNA00179
• Links
  HGNC:37117

  NCBI Gene ID: 100506311

  
  
• Chr Location
  chr7:27095647-27100265 (+)  GRCh38

---

• MGI Vertebrate Homology
  Hotairm1 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: HOTAIRM1
• Gene Tree
  Hotairm1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  20
• Gene trapped
  19
• Targeted
  1
• Genomic Mutations
  1 involving Hotairm1
• Find Mice (IMSR)
  5 strains or lines available

Expression

• Assay Results
  597

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  29
• RefSeq
  1

• Ensembl
  ENSMUSG00000087658 (Evidence)
• NCBI Gene
  105242658

Representative Sequences			Length	Strain/Species
genomic	105242658	NCBI Gene Model | MGI Sequence Detail	3497	C57BL/6J
transcript	NR_131181	RefSeq | MGI Sequence Detail	253	ZRU/MplStud

References

• Summaries
  All 20

  Phenotypes 12
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:322498 Chen W, et al., Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion. J Immunol. 2022 Feb 1;208(3):618-632