Cstdc6 MGI Mouse Gene Detail - MGI:3696881 - cystatin domain containing 6

Symbol

Cstdc6
Name

cystatin domain containing 6
Synonyms

BC117090, Gm1975

Feature Type

protein coding gene
IDs

MGI:3696881
NCBI Gene: 100038854
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:36142027-36154694 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.47 cM
Mapping Data

2 experiments

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3696881	protein coding gene	Chr16:36142027-36154694 (-)
129S1/SvImJ	ENSMUSG00200027485	protein coding gene	Chr16:33084676-33090190 (-)
A/J	ENSMUSG00195010990	protein coding gene	Chr16:32636314-32641828 (-)
AKR/J	ENSMUSG00220026227	protein coding gene	Chr16:32988634-33001301 (+)
BALB/cJ	ENSMUSG00180012633	protein coding gene	Chr16:32851989-32857503 (-)
C3H/HeJ	ENSMUSG00175027677	protein coding gene	Chr16:33065345-33078012 (-)
C57BL/6NJ	ENSMUSG00215017073	protein coding gene	Chr16:32913096-32925763 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005030044	protein coding gene	Chr16:33330063-33342736 (-)
CBA/J	ENSMUSG00210026611	protein coding gene	Chr16:33122458-33135125 (-)
DBA/2J	ENSMUSG00185023204	protein coding gene	Chr16:33025460-33038127 (-)
FVB/NJ	ENSMUSG00205016306	protein coding gene	Chr16:32984089-32989603 (-)
JF1/MsJ	ENSUMUG00000029112	protein coding gene	Chr16:33219957-33225393 (-)
LP/J	ENSMUSG00230031971	protein coding gene	Chr16:35604715-35610453 (-)
NOD/ShiLtJ	ENSMUSG00190021406	protein coding gene	Chr16:33144865-33150379 (-)
NZO/HlLtJ	ENSMUSG00225037889	protein coding gene	Chr16:38704054-38709792 (-)
PWK/PhJ	ENSLUMG00010026600	protein coding gene	Chr16:33122896-33128314 (-)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005026474	protein coding gene	Chr16:33181799-33201218 (-)

Human Ortholog

CSTA, cystatin A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTA, cystatin A
Synonyms

AREI, PSS4, STF1, STFA
Links

HGNC:2481

NCBI Gene ID: 1475

UniProt: P01040
Chr Location

3q21.1; chr3:122325248-122341969 (+) GRCh38

MGI Vertebrate Homology

Cstdc6 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CSTA
Gene Tree

Cstdc6

Diseases

1 with human CSTA associations

				Human Disease	Mouse Models
				peeling skin syndrome 4 IDs peeling skin syndrome 4 DOID:0070523 MESH:C564309 OMIM:607936

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype reference

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

2
CCDS

CCDS49840.1

Ensembl

ENSMUSG00000079594 (Evidence)
NCBI Gene

100038854

			Length	Strain/Species	Flank
genomic	100038854	NCBI Gene Model \| MGI Sequence Detail	12668	C57BL/6J	± kb
transcript	NM_001001332	RefSeq \| MGI Sequence Detail	387	Not Specified
polypeptide	NP_001001332	RefSeq \| MGI Sequence Detail	96	Not Specified

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UniProt

2 Sequences
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR001713 Proteinase inhibitor I25A, stefin

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Microarray probesets 1

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MGI:3780144, MGI:6275076

Summaries

All 15

Gene Ontology 4

Phenotypes 1
Earliest

J:23000 MGD Nomenclature Committee, Nomenclature Committee Use. 1995-02-14;
Latest

J:389486 Mouse Genome Informatics and Ensembl Genome Database Project, MGI Strain Genome Feature and Gene Model Load from Ensembl. Database Release. 2026;

TSS for Cstdc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140983	Chr16:36154692-36154709 (-)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29