Morrbid MGI Mouse Gene Detail - MGI:3652191 - myeloid RNA regulator of BCL2L11 induced cell death

Symbol

Morrbid
Name

myeloid RNA regulator of BCL2L11 induced cell death
Synonyms

Cytor, Mir4435-2hg

Feature Type

lncRNA gene
IDs

MGI:3652191
NCBI Gene: 100043424
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:128140583-128271271 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.31 cM

SNPs within 2kb

1235 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3652191	lncRNA gene	Chr2:128020239-128344685 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015466	unclassified non-coding RNA gene	Chr2:131517324-131764080 (-)
A/J	MGP_AJ_G0015442	unclassified non-coding RNA gene	Chr2:126195394-126432522 (-)
AKR/J	MGP_AKRJ_G0015406	unclassified non-coding RNA gene	Chr2:129790080-130031945 (-)
BALB/cJ	MGP_BALBcJ_G0015405	unclassified non-coding RNA gene	Chr2:126453572-126692823 (-)
C3H/HeJ	MGP_C3HHeJ_G0015228	unclassified non-coding RNA gene	Chr2:130298944-130535670 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0015859	unclassified non-coding RNA gene	Chr2:135641012-135886389 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013598	unclassified non-coding RNA gene	Chr2:121024538-121260422 (-)
CAST/EiJ	MGP_CASTEiJ_G0014780	unclassified non-coding RNA gene	Chr2:130514537-130765772 (-)
CBA/J	MGP_CBAJ_G0015209	unclassified non-coding RNA gene	Chr2:140657565-140905020 (-)
DBA/2J	MGP_DBA2J_G0015303	unclassified non-coding RNA gene	Chr2:125592547-125827222 (-)
FVB/NJ	MGP_FVBNJ_G0015310	unclassified non-coding RNA gene	Chr2:124238122-124473382 (-)
LP/J	MGP_LPJ_G0015381	unclassified non-coding RNA gene	Chr2:131754732-132002377 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015334	unclassified non-coding RNA gene	Chr2:144637300-144877986 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015899	unclassified non-coding RNA gene	Chr2:129807142-130046496 (-)
PWK/PhJ	MGP_PWKPhJ_G0014568	unclassified non-coding RNA gene	Chr2:125155875-125395943 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014356	unclassified non-coding RNA gene	Chr2:128910855-129154797 (-)
WSB/EiJ	MGP_WSBEiJ_G0014887	unclassified non-coding RNA gene	Chr2:130718224-130961249 (-)

Human Ortholog

MIR4435-2HG, MIR4435-2 host gene

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR4435-2HG, MIR4435-2 host gene
Synonyms

AGD2, LINC00978, lncRNA-AWPPH, MIR4435-1HG, MORRBID
Links

HGNC:35163

NCBI Gene ID: 541471
Chr Location

2q13; chr2:111006015-111523376 (-) GRCh38

MGI Vertebrate Homology

Morrbid stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR4435-2HG
Gene Tree

Morrbid

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

1
Genomic Mutations

2 involving Morrbid
Find Mice (IMSR)

23 strains or lines available

Mice homozygous or heterozygous for a knock-out allele exhibit decreased eosinophil, neutrophils and monocytes sue to increased apoptosis, and increased sensitivity to L. monocytogenes infection.

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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

89
RefSeq

3
UniProt

1

Ensembl

ENSMUSG00000074813 (Evidence)
NCBI Gene

100043424

			Length	Strain/Species	Flank
genomic	100043424	NCBI Gene Model \| MGI Sequence Detail	130689	C57BL/6J	± kb
transcript	NR_028589	RefSeq \| MGI Sequence Detail	2797	C57BL/6
polypeptide	Q3U050	UniProt \| EBI \| MGI Sequence Detail	133	Not Applicable

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UniProt

1 Sequence

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 26

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:331044 Cai Z, et al., Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid. J Clin Invest. 2021 Jan 4;131(1)

TSS for Morrbid:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26169	Chr2:128271305-128271319 (-)	-41 bp
Tssr26168	Chr2:128271237-128271282 (-)	11 bp
Tssr26167	Chr2:128271156-128271179 (-)	103 bp
Tssr26166	Chr2:128271097-128271146 (-)	149 bp
Tssr26165	Chr2:128271077-128271086 (-)	189 bp
Tssr26164	Chr2:128271061-128271066 (-)	207 bp
Tssr26163	Chr2:128270993-128271011 (-)	269 bp
Tssr645	Chr2:128270836-128270853 (-)	426 bp
Tssr26162	Chr2:128264138-128264161 (-)	7,121 bp
Tssr26161	Chr2:128248556-128248560 (-)	22,713 bp
Tssr644	Chr2:128248393-128248397 (-)	22,876 bp
Tssr26160	Chr2:128247179-128247190 (-)	24,086 bp
Tssr26159	Chr2:128224527-128224541 (-)	46,737 bp
Tssr26158	Chr2:128181409-128181411 (-)	89,861 bp
Tssr26157	Chr2:128160799-128160809 (-)	110,467 bp
Tssr26156	Chr2:128148512-128148525 (-)	122,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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