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Gas2l2 Gene Detail
Summary
  • Symbol
    Gas2l2
  • Name
    growth arrest-specific 2 like 2
  • Synonyms
    OTTMUSG00000000934
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652048
    NCBI Gene: 237891
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83312728-83320281 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.33 cM
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652048
 protein coding gene Chr11:83312461-83320347 (-)
129S1/SvImJ ENSMUSG00200051143
 protein coding gene Chr11:80432656-80440213 (-)
A/J ENSMUSG00195039570
 protein coding gene Chr11:80287108-80294663 (-)
AKR/J ENSMUSG00220047068
 protein coding gene Chr11:80509074-80516645 (-)
BALB/cJ ENSMUSG00180034690
 protein coding gene Chr11:80501787-80509344 (-)
C3H/HeJ ENSMUSG00175036402
 protein coding gene Chr11:80434130-80441685 (-)
C57BL/6NJ ENSMUSG00215041667
 protein coding gene Chr11:80085413-80092966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016873
 protein coding gene Chr11:78658302-78665815 (-)
CAST/EiJ ENSTCUG00005040200
 protein coding gene Chr11:79961632-79969145 (-)
CBA/J ENSMUSG00210034163
 protein coding gene Chr11:80251756-80259311 (-)
DBA/2J ENSMUSG00185035971
 protein coding gene Chr11:80587017-80594573 (-)
FVB/NJ ENSMUSG00205041641
 protein coding gene Chr11:80389345-80396904 (-)
JF1/MsJ ENSUMUG00000021760
 protein coding gene Chr11:80906547-80914069 (-)
LP/J ENSMUSG00230028005
 protein coding gene Chr11:81601908-81609463 (-)
NOD/ShiLtJ ENSMUSG00190037768
 protein coding gene Chr11:80601671-80609238 (-)
NZO/HlLtJ ENSMUSG00225037878
 protein coding gene Chr11:83735298-83742853 (-)
PWK/PhJ ENSLUMG00010023296
 protein coding gene Chr11:80421312-80428907 (-)
SPRET/EiJ ENSMSPG00010037941
 protein coding gene Chr11:80815124-80822653 (-)
WSB/EiJ ENSIUOG00005034702
 protein coding gene Chr11:80409757-80417299 (-)



Homology
more
  • Human Ortholog
    GAS2L2, growth arrest specific 2 like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAS2L2, growth arrest specific 2 like 2
  • Synonyms
    CILD41, GAR17
  • Links
    NCBI Gene ID: 246176
    UniProt: Q8NHY3

  • Chr Location
    17q12; chr17:35744511-35753260 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gas2l2 mouse models; 1 with human GAS2L2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 2 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hydrocephaly, dextrocardia, situs ambiguus, abnormal tracheal ciliated epithelium morphology, impaired mucociliary clearance, and partial neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020686 Ensembl Gene Model | MGI Sequence Detail 7554 C57BL/6J ±  kb
    transcript ENSMUST00000052521 Ensembl | MGI Sequence Detail 2610 Not Applicable  
    polypeptide ENSMUSP00000051907 Ensembl | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1
      Genomic 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory