Ttc39aos1 Gene Detail

Summary

• Symbol
  Ttc39aos1
• Name
  Ttc39a opposite strand RNA 1
• Synonyms
  Gm12750, LincRNA-EPS

• Feature Type
  antisense lncRNA gene
  BioType Conflict
  
• IDs
  MGI:3651956
  NCBI Gene: 102635290
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr4:109259476-109263430 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 51.29 cM

Strain
Comparison

• SNPs within 2kb
  250 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3651956	antisense lncRNA gene	Chr4:109259476-109263454 (-)
129S1/SvImJ	ENSMUSG00200049774	lncRNA gene	Chr4:104305105-104309098 (-)
A/J	ENSMUSG00195047637	lncRNA gene	Chr4:104855351-104859345 (-)
AKR/J	ENSMUSG00220012528	lncRNA gene	Chr4:104223085-104227082 (-)
BALB/cJ	ENSMUSG00180048023	lncRNA gene	Chr4:103686840-103690794 (-)
C3H/HeJ	ENSMUSG00175043084	lncRNA gene	Chr4:104691132-104695086 (-)
C57BL/6NJ	ENSMUSG00215035964	lncRNA gene	Chr4:104593003-104596957 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003538	antisense lncRNA gene	Chr4:101506236-101508612 (-)
CAST/EiJ	ENSTCUG00005023001	lncRNA gene	Chr4:103792739-103796667 (-)
CBA/J	ENSMUSG00210053293	lncRNA gene	Chr4:104324155-104328109 (-)
DBA/2J	ENSMUSG00185050576	lncRNA gene	Chr4:105021232-105025222 (-)
FVB/NJ	ENSMUSG00205043730	lncRNA gene	Chr4:103258555-103262547 (-)
JF1/MsJ	ENSUMUG00000047409	lncRNA gene	Chr4:105042675-105046215 (-)
LP/J	ENSMUSG00230009396	lncRNA gene	Chr4:108341415-108345405 (-)
NOD/ShiLtJ	ENSMUSG00190048157	lncRNA gene	Chr4:103693930-103697884 (-)
NZO/HlLtJ	ENSMUSG00225011462	lncRNA gene	Chr4:113442776-113446730 (-)
PWK/PhJ	ENSLUMG00010047650	lncRNA gene	Chr4:102753143-102756687 (-)
SPRET/EiJ	ENSMSPG00010029680	lncRNA gene	Chr4:104986540-104991033 (-)
WSB/EiJ	ENSIUOG00005045225	lncRNA gene	Chr4:103880923-103884915 (-)

Homology

• Gene Tree
  Ttc39aos1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 2 alleles in 2 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  2
• Endonuclease-mediated
  3
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  4 involving Ttc39aos1
• Find Mice (IMSR)
  2 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice exhibit increased susceptibility to LPS-induced endotoxin shock and to induced acute pancreatitis.

Expression

• Assay Results
  597
• cDNA Data
  1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  1

• Ensembl
  ENSMUSG00000085873 (Evidence)
• NCBI Gene
  102635290

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000085873	Ensembl Gene Model | MGI Sequence Detail	3955	C57BL/6J
transcript	ENSMUST00000247239	Ensembl | MGI Sequence Detail	2480	Not Applicable

Molecular
Reagents

• All nucleic 1

  cDNA 1

References

• Summaries
  All 18

  Phenotypes 10
• Earliest
  J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
• Latest
  J:327556 Zhu J, et al., LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction. EMBO Rep. 2022 May 4;23(5):e53937

TSS for Ttc39aos1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42761	Chr4:109263442-109263459 (-)	-21 bp