Arhgap40 MGI Mouse Gene Detail - MGI:3649852 - Rho GTPase activating protein 40

Symbol

Arhgap40
Name

Rho GTPase activating protein 40
Synonyms

Gm14203

Feature Type

protein coding gene
IDs

MGI:3649852
NCBI Gene: 545481
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:158354716-158392682 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM

SNPs within 2kb

1398 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3649852	protein coding gene	Chr2:158354682-158392786 (+)
129S1/SvImJ	ENSMUSG00200015425	protein coding gene	Chr2:155211168-155249133 (+)
A/J	ENSMUSG00195021587	protein coding gene	Chr2:155579130-155616728 (+)
AKR/J	ENSMUSG00220011975	protein coding gene	Chr2:154908354-154945964 (+)
BALB/cJ	ENSMUSG00180042400	protein coding gene	Chr2:155032570-155070176 (+)
C3H/HeJ	ENSMUSG00175050305	protein coding gene	Chr2:155782702-155820292 (+)
C57BL/6NJ	ENSMUSG00215014804	protein coding gene	Chr2:155204355-155242322 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024590	protein coding gene	Chr2:150468665-150507836 (+)
CAST/EiJ	ENSTCUG00005045956	protein coding gene	Chr2:154183624-154221676 (+)
CBA/J	ENSMUSG00210015444	protein coding gene	Chr2:155713816-155751406 (+)
DBA/2J	ENSMUSG00185047126	protein coding gene	Chr2:155432690-155470692 (+)
FVB/NJ	ENSMUSG00205043112	protein coding gene	Chr2:154464928-154502534 (+)
JF1/MsJ	ENSUMUG00000012654	protein coding gene	Chr2:155088901-155126897 (+)
LP/J	ENSMUSG00230044583	protein coding gene	Chr2:157008683-157046648 (+)
NOD/ShiLtJ	ENSMUSG00190039701	protein coding gene	Chr2:155107816-155145408 (+)
NZO/HlLtJ	ENSMUSG00225049172	protein coding gene	Chr2:165023319-165060887 (+)
PWK/PhJ	ENSLUMG00010047208	protein coding gene	Chr2:155027640-155066167 (+)
SPRET/EiJ	ENSMSPG00010032436	protein coding gene	Chr2:157790833-157829835 (+)
WSB/EiJ	ENSIUOG00005045155	protein coding gene	Chr2:154808400-154846373 (+)

Human Ortholog

ARHGAP40, Rho GTPase activating protein 40

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP40, Rho GTPase activating protein 40
Synonyms

C20orf95, dJ1100H13.4
Links

HGNC:16226

NCBI Gene ID: 343578

UniProt: Q5TG30
Chr Location

20q11.23; chr20:38601775-38651035 (+) GRCh38

MGI Vertebrate Homology

Arhgap40 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARHGAP40
Gene Tree

Arhgap40

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap40

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All Sequences

28
RefSeq

2
UniProt

2
CCDS

CCDS50787.1

Ensembl

ENSMUSG00000074625 (Evidence)
NCBI Gene

545481

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074625	Ensembl Gene Model \| MGI Sequence Detail	37967	C57BL/6J	± kb
transcript	ENSMUST00000099133	Ensembl \| MGI Sequence Detail	2162	Not Applicable
polypeptide	ENSMUSP00000096736	Ensembl \| MGI Sequence Detail	672	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030342 Rho GTPase-activating protein 40

(term hierarchy)
InterPro Domains

IPR057323 RHG40/28/18, C-terminal ubiquitin-like domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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Microarray probesets 1

Summaries

All 20

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap40:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21355	Chr2:158354667-158354691 (+)	-37 bp
Tssr21356	Chr2:158354725-158354732 (+)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24