Gm12250 Pseudogene Detail

Summary

• Symbol
  Gm12250
• Name
  predicted gene 12250
• Synonyms
  Irgb10

• Feature Type
  pseudogene
  BioType Conflict
  
• IDs
  MGI:3649299
  NCBI Gene: 631323
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr11:58074669-58081024 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 35.96 cM

Strain
Comparison

• SNPs within 2kb
  69 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3649299	pseudogene	Chr11:58074623-58081024 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0010725	pseudogene	Chr11:57863496-57864769 (+)
A/J	MGP_AJ_G0010721	pseudogene	Chr11:55674906-55676179 (+)
AKR/J	MGP_AKRJ_G0010679	pseudogene	Chr11:57502110-57503383 (+)
BALB/cJ	MGP_BALBcJ_G0010693	pseudogene	Chr11:56014724-56015997 (+)
C3H/HeJ	MGP_C3HHeJ_G0010605	pseudogene	Chr11:57435788-57437061 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0010968	pseudogene	Chr11:59642503-59643776 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0009599	pseudogene	Chr11:53025131-53026404 (+)
CAST/EiJ	MGP_CASTEiJ_G0010428	pseudogene	Chr11:57530877-57532150 (+)
CBA/J	MGP_CBAJ_G0010580	pseudogene	Chr11:62391130-62392403 (+)
DBA/2J	MGP_DBA2J_G0010618	pseudogene	Chr11:55320537-55321810 (+)
FVB/NJ	MGP_FVBNJ_G0010634	pseudogene	Chr11:55016530-55017803 (+)
LP/J	MGP_LPJ_G0010705	pseudogene	Chr11:58399885-58401158 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0010608	pseudogene	Chr11:63510545-63511818 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0010941	pseudogene	Chr11:57544727-57546000 (+)
PWK/PhJ	MGP_PWKPhJ_G0010323	pseudogene	Chr11:55926296-55927569 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0010132	pseudogene	Chr11:57424592-57425865 (+)
WSB/EiJ	MGP_WSBEiJ_G0010485	pseudogene	Chr11:57175894-57177167 (+)

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Genomic Mutations
  1 involving Gm12250
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  32
• GO References
  14

Expression

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  1

• Ensembl
  ENSMUSG00000082292 (Evidence), ENSMUSG00000134402 (Evidence)
• NCBI Gene
  631323

Representative Sequences			Length	Strain/Species
genomic	631323	NCBI Gene Model | MGI Sequence Detail	6356	C57BL/6J
transcript	NM_001135115	RefSeq | MGI Sequence Detail	2702	C57BL/6
polypeptide	Q0GUM3	UniProt | EBI | MGI Sequence Detail	417	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• PDB
  7C3K
• EC
  3.6.5.-
• InterPro Domains
  IPR051515 Immunity-related GTPase
  IPR007743 Immunity-related GTPases-like
  IPR030385 IRG-type guanine nucleotide-binding (G) domain
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• 
  

  Microarray probesets 1

References

• Summaries
  All 28

  Gene Ontology 14

  Phenotypes 9
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:333980 Christgen S, et al., The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. Eur J Immunol. 2022 Feb;52(2):285-296

TSS for Gm12250:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101685	Chr11:58074621-58074643 (+)	-37 bp
Tssr101686	Chr11:58074652-58074697 (+)	6 bp
Tssr101687	Chr11:58074712-58074723 (+)	49 bp
Tssr101688	Chr11:58074744-58074757 (+)	82 bp
Tssr101689	Chr11:58074761-58074773 (+)	98 bp