Gm12250 Pseudogene Detail

Summary

• Symbol
  Gm12250
• Name
  predicted gene 12250
• Synonyms
  Irgb10

• Feature Type
  pseudogene
  BioType Conflict
  
• IDs
  MGI:3649299
  NCBI Gene: 631323
• Alliance
  genome feature page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr11:58074669-58081024 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 35.96 cM

Strain
Comparison

• SNPs within 2kb
  69 from dbSNP Build 142
• Strain Annotations
  20

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3649299	pseudogene	Chr11:58074623-58081024 (+)
129S1/SvImJ	ENSMUSG00200037400	pseudogene	Chr11:55077478-55078751 (+)
A/J	ENSMUSG00195041643	pseudogene	Chr11:55011585-55012858 (+)
AKR/J	ENSMUSG00220050246	pseudogene	Chr11:55173833-55175106 (+)
BALB/cJ	ENSMUSG00180050475	pseudogene	Chr11:55093851-55095124 (+)
C3H/HeJ	ENSMUSG00175049973	pseudogene	Chr11:55046874-55048147 (+)
C57BL/6NJ	ENSMUSG00215040374	pseudogene	Chr11:54868564-54869837 (+)
C57BL/6NJ	ENSMUSG00215039094	protein coding gene	Chr11:54864643-54870987 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0009599	pseudogene	Chr11:53025131-53026404 (+)
CAST/EiJ	ENSTCUG00005047896	pseudogene	Chr11:54586052-54587325 (+)
CBA/J	ENSMUSG00210040826	pseudogene	Chr11:54898267-54899540 (+)
DBA/2J	ENSMUSG00185044445	pseudogene	Chr11:55083143-55084416 (+)
FVB/NJ	ENSMUSG00205050867	pseudogene	Chr11:54951031-54952304 (+)
JF1/MsJ	ENSUMUG00000048785	pseudogene	Chr11:55431282-55432555 (+)
LP/J	ENSMUSG00230050488	pseudogene	Chr11:56284328-56285601 (+)
NOD/ShiLtJ	ENSMUSG00190051280	pseudogene	Chr11:55137129-55138402 (+)
NZO/HlLtJ	ENSMUSG00225033329	pseudogene	Chr11:58300009-58301282 (+)
PWK/PhJ	ENSLUMG00010037667	pseudogene	Chr11:54889991-54891264 (+)
SPRET/EiJ	ENSMSPG00010042476	pseudogene	Chr11:55676799-55678072 (+)
WSB/EiJ	ENSIUOG00005039218	pseudogene	Chr11:54939944-54941217 (+)

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Genomic Mutations
  1 involving Gm12250
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  26
• GO References
  13

Expression

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  1

• Ensembl
  ENSMUSG00000082292 (Evidence), ENSMUSG00000134402 (Evidence)
• NCBI Gene
  631323

Representative Sequences			Length	Strain/Species
genomic	631323	NCBI Gene Model | MGI Sequence Detail	6356	C57BL/6J
transcript	NM_001135115	RefSeq | MGI Sequence Detail	2702	C57BL/6
polypeptide	Q0GUM3	UniProt | EBI | MGI Sequence Detail	417	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• PDB
  7C3K
• EC
  3.6.5.-
• InterPro Domains
  IPR051515 Immunity-related GTPase
  IPR007743 Immunity-related GTPases-like
  IPR030385 IRG-type guanine nucleotide-binding (G) domain
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• 
  

  Microarray probesets 1

References

• Summaries
  All 30

  Gene Ontology 13

  Phenotypes 9
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:352156 Singh S, et al., ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence. PLoS Pathog. 2023 Jan;19(1):e1011003

TSS for Gm12250:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101685	Chr11:58074621-58074643 (+)	-37 bp
Tssr101686	Chr11:58074652-58074697 (+)	6 bp
Tssr101687	Chr11:58074712-58074723 (+)	49 bp
Tssr101688	Chr11:58074744-58074757 (+)	82 bp
Tssr101689	Chr11:58074761-58074773 (+)	98 bp