Fam181a MGI Mouse Gene Detail - MGI:3647570 - family with sequence similarity 181, member A

Symbol

Fam181a
Name

family with sequence similarity 181, member A
Synonyms

EG544888

Feature Type

protein coding gene
IDs

MGI:3647570
NCBI Gene: 100504156
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:103277272-103283326 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.90 cM
Mapping Data

2 experiments

SNPs within 2kb

267 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3647570	protein coding gene	Chr12:103277234-103283326 (+)
129S1/SvImJ	ENSMUSG00200022889	protein coding gene	Chr12:95077392-95083483 (+)
A/J	ENSMUSG00195018588	protein coding gene	Chr12:97604174-97610266 (+)
AKR/J	ENSMUSG00220036372	protein coding gene	Chr12:95551895-95557984 (+)
BALB/cJ	ENSMUSG00180032483	protein coding gene	Chr12:96797886-96803979 (+)
C3H/HeJ	ENSMUSG00175030829	protein coding gene	Chr12:99416932-99423024 (+)
C57BL/6NJ	ENSMUSG00215040380	protein coding gene	Chr12:96078821-96084913 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018049	protein coding gene	Chr12:97992558-97998580 (+)
CAST/EiJ	ENSTCUG00005017840	protein coding gene	Chr12:95468341-95474451 (+)
CBA/J	ENSMUSG00210013765	protein coding gene	Chr12:96451233-96457324 (+)
DBA/2J	ENSMUSG00185043068	protein coding gene	Chr12:98255899-98261988 (+)
FVB/NJ	ENSMUSG00205011666	protein coding gene	Chr12:95469097-95475187 (+)
JF1/MsJ	ENSUMUG00000013727	protein coding gene	Chr12:102991181-102997247 (+)
LP/J	ENSMUSG00230028901	protein coding gene	Chr12:105342375-105348464 (+)
NOD/ShiLtJ	ENSMUSG00190019949	protein coding gene	Chr12:89680555-89686645 (-)
NZO/HlLtJ	ENSMUSG00225037961	protein coding gene	Chr12:107053723-107059813 (+)
PWK/PhJ	ENSLUMG00010011779	protein coding gene	Chr12:96428566-96434644 (+)
SPRET/EiJ	ENSMSPG00010017841	protein coding gene	Chr12:98945513-98951531 (+)
WSB/EiJ	ENSIUOG00005007344	protein coding gene	Chr12:95482573-95488662 (+)

Human Ortholog

FAM181A, family with sequence similarity 181 member A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM181A, family with sequence similarity 181 member A
Synonyms

C14orf152
Links

HGNC:20491

NCBI Gene ID: 90050

UniProt: Q8N9Y4
Chr Location

14q32.12; chr14:93918894-93929608 (+) GRCh38

MGI Vertebrate Homology

Fam181a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FAM181A
Gene Tree

Fam181a

less

Phenotype Summary

1 phenotype from multigenic genotypes
3 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Fam181a
Find Mice (IMSR)

11 strains or lines available

Male mice homozygous for a null allele exhibit normal fertility.

less

All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

689
Tissues

42
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam181a

less

All Sequences

42
RefSeq

12
UniProt

2
CCDS

CCDS56858.1

Ensembl

ENSMUSG00000096753 (Evidence)
NCBI Gene

100504156

			Length	Strain/Species	Flank
genomic	100504156	NCBI Gene Model \| MGI Sequence Detail	6055	C57BL/6J	± kb
transcript	NM_001413260	RefSeq \| MGI Sequence Detail	1418	C57BL/6
polypeptide	NP_001400190	RefSeq \| MGI Sequence Detail	292	C57BL/6

less

UniProt

2 Sequences
InterPro Domains

IPR029359 FAM181

IPR053819 TEAD interacting region 3, omega loop

less

All nucleic 2

cDNA 1

Primer pair 1

Microarray probesets 3

less

MGI:2144900

Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 3
Earliest

J:228526 Marks M, et al., Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene. 2016 Jan 10;575(2 Pt 2):438-51
Latest

J:324697 Shah W, et al., Knockout of the family with sequence similarity 181, member A (Fam181a) gene does not impair spermatogenesis or male fertility in the mouse. Reprod Fertil Dev. 2021 Jul 13;

TSS for Fam181a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114795	Chr12:103277269-103277289 (+)	7 bp
Tssr114796	Chr12:103281116-103281151 (+)	3,862 bp
Tssr114797	Chr12:103281203-103281221 (+)	3,940 bp
Tssr114798	Chr12:103281226-103281233 (+)	3,958 bp
Tssr114799	Chr12:103281237-103281248 (+)	3,971 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29