Defa-ps12 Pseudogene Detail

Summary

• Symbol
  Defa-ps12
• Name
  defensin, alpha, pseudogene 12

• Feature Type
  pseudogene
• IDs
  MGI:3647175
  NCBI Gene: 654452
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr8:19260478-19262776 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 10.35 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  222 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3647175	pseudogene	Chr8:19260478-19262783 (+)
129S1/SvImJ	ENSMUSG00200033765	pseudogene	Chr8:16066205-16068508 (+)
A/J	ENSMUSG00195043291	pseudogene	Chr8:16489281-16491584 (+)
AKR/J	ENSMUSG00220032947	pseudogene	Chr8:16258550-16260855 (+)
BALB/cJ	ENSMUSG00180026143	pseudogene	Chr8:16109638-16111941 (+)
C3H/HeJ	ENSMUSG00175040120	pseudogene	Chr8:16287692-16289995 (+)
C57BL/6NJ	ENSMUSG00215032802	pseudogene	Chr8:16230601-16232906 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005019899	pseudogene	Chr8:16058698-16060988 (+)
CBA/J	ENSMUSG00210043420	pseudogene	Chr8:16126528-16128831 (+)
DBA/2J	ENSMUSG00185006910	pseudogene	Chr8:16254328-16256631 (+)
FVB/NJ	ENSMUSG00205033436	pseudogene	Chr8:16135811-16138116 (+)
JF1/MsJ	ENSUMUG00000034709	pseudogene	Chr8:16142327-16144123 (+)
LP/J	ENSMUSG00230024205	pseudogene	Chr8:18339099-18341403 (+)
NOD/ShiLtJ	ENSMUSG00190038067	pseudogene	Chr8:16258776-16261079 (+)
NZO/HlLtJ	ENSMUSG00225042528	pseudogene	Chr8:26194006-26196311 (+)
PWK/PhJ	ENSLUMG00010030390	pseudogene	Chr8:16122221-16124539 (+)
SPRET/EiJ	ENSMSPG00010015099	pseudogene	Chr8:16363979-16366298 (+)
WSB/EiJ	ENSIUOG00005021447	pseudogene	Chr8:16200412-16202721 (+)

Homology

• Gene Tree
  Defa-ps12
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Genomic Mutations
  1 involving Defa-ps12
• Find Mice (IMSR)
  0 strains or lines available

Expression

• Assay Results
  597

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  24
• RefSeq
  2

• Ensembl
  ENSMUSG00000081163 (Evidence)
• NCBI Gene
  654452

Representative Sequences			Length	Strain/Species
genomic	654452	NCBI Gene Model | MGI Sequence Detail	2299	C57BL/6J
transcript	NR_197399	RefSeq | MGI Sequence Detail	241	C57BL/6

References

• Summaries
  All 7

  Phenotypes 1
• Earliest
  J:101568 Patil AA, et al., Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17
• Latest
  J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662