Lrrc74a Gene Detail

Summary

• Symbol
  Lrrc74a
• Name
  leucine rich repeat containing 74A
• Synonyms
  Gm6772, Lrrc74

• Feature Type
  protein coding gene
• IDs
  MGI:3646959
  NCBI Gene: 627607
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr12:86781143-86810571 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 40.90 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  116 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646959	protein coding gene	Chr12:86781119-86815799 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019973	protein coding gene	Chr12:87596168-87626250 (+)
A/J	MGP_AJ_G0019930	protein coding gene	Chr12:84262926-84292477 (+)
AKR/J	MGP_AKRJ_G0019906	protein coding gene	Chr12:86549603-86580497 (+)
BALB/cJ	MGP_BALBcJ_G0019910	protein coding gene	Chr12:84605174-84634433 (+)
C3H/HeJ	MGP_C3HHeJ_G0019716	protein coding gene	Chr12:87029504-87060421 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020361	protein coding gene	Chr12:90108096-90138790 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017979	protein coding gene	Chr12:81152524-81185422 (+)
CAST/EiJ	MGP_CASTEiJ_G0019266	protein coding gene	Chr12:82035036-82065456 (+)
CBA/J	MGP_CBAJ_G0019687	protein coding gene	Chr12:93575870-93613705 (+)
DBA/2J	MGP_DBA2J_G0019801	protein coding gene	Chr12:83765655-83794684 (+)
FVB/NJ	MGP_FVBNJ_G0019788	protein coding gene	Chr12:82745644-82777407 (+)
LP/J	MGP_LPJ_G0019875	protein coding gene	Chr12:87469698-87500308 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019827	protein coding gene	Chr12:96338339-96370555 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020394	protein coding gene	Chr12:86174759-86207048 (+)
PWK/PhJ	MGP_PWKPhJ_G0019029	protein coding gene	Chr12:78313844-78343231 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018825	protein coding gene	Chr12:80667220-80699408 (+)
WSB/EiJ	MGP_WSBEiJ_G0019318	protein coding gene	Chr12:86917928-86947934 (+)

Homology

• Human Ortholog
  LRRC74A, leucine rich repeat containing 74A

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRRC74A, leucine rich repeat containing 74A
  
• Synonyms
  C14orf166B, LRRC74
• Links
  HGNC:23346

  NCBI Gene ID: 145497

  neXtProt AC: NX_Q0VAA2

  UniProt: Q0VAA2

  
  
• Chr Location
  14q24.3; chr14:76826370-76870302 (+)  GRCh38.p7

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• Alliance of Genome Resources
  Lrrc74a stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: LRRC74A
• Gene Tree
  Lrrc74a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (other)
  1
• Genomic Mutations
  1 involving Lrrc74a
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  12 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Interactions

• Lrrc74a interacts with 38 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  55
• RefSeq
  22
• UniProt
  4
• CCDS
  CCDS56848.1

• Ensembl
  ENSMUSG00000059114 (Evidence)
• NCBI Gene
  627607

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000059114	Ensembl Gene Model | MGI Sequence Detail	29429	C57BL/6J
transcript	ENSMUST00000223308	Ensembl | MGI Sequence Detail	1854	Not Applicable
polypeptide	ENSMUSP00000152661	Ensembl | MGI Sequence Detail	494	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• InterPro Domains
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain superfamily

Molecular
Reagents

• All nucleic 1

  cDNA 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2144854

References

• Summaries
  All 15

  Phenotypes 2
• Earliest
  J:23389 Roderick TH, Using inversions to detect and study recessive lethals and detrimentals in mice, in Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. 1983:135-67.
• Latest
  J:157972 Mouse Genome Informatics Scientific Curators, Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). Database Download. 2010;

TSS for Lrrc74a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114474	Chr12:86781116-86781123 (+)	-23 bp
Tssr114475	Chr12:86781139-86781151 (+)	2 bp
Tssr114476	Chr12:86781155-86781191 (+)	30 bp