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Vmn2r116 Gene Detail
Summary
  • Symbol
    Vmn2r116
  • Name
    vomeronasal 2, receptor 116
  • Synonyms
    EG619697, V2Rp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646674
    NCBI Gene: 619697
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr17:23603777-23620838 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646674
protein coding gene Chr17:23603578-23623396 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0023220
protein coding gene Chr17:21843891-21865663 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023662
protein coding gene Chr17:23181122-23255036 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0022485
protein coding gene Chr17:21871660-21893454 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0023074
protein coding gene Chr17:23699337-23724543 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023702
protein coding gene Chr17:21962730-21982735 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 619697 NCBI Gene Model | MGI Sequence Detail 17062 C57BL/6J ±  kb
    transcript NM_001104580 RefSeq | MGI Sequence Detail 2571 C57BL/6  
    polypeptide E9Q6I0 UniProt | EBI | MGI Sequence Detail 856 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR004073 GPCR, family 3, vomeronasal receptor, type 2
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    References
    more
    • Summaries
      All 13
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:125082 Young JM, et al., V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Trends Genet. 2007 May;23(5):212-5
    • Latest
      J:267556 Osakada T, et al., Sexual rejection via a vomeronasal receptor-triggered limbic circuit. Nat Commun. 2018 Oct 26;9(1):4463

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/13/2024
    MGI 6.23
    The Jackson Laboratory