Defb46 Gene Detail

Summary

• Symbol
  Defb46
• Name
  defensin beta 46

• Feature Type
  protein coding gene
• IDs
  MGI:3646525
  NCBI Gene: 574081
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr8:19289932-19292159 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 10.35 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  263 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646525	protein coding gene	Chr8:19289932-19292159 (+)
129S1/SvImJ	ENSMUSG00200029131	protein coding gene	Chr8:16095661-16097858 (+)
A/J	ENSMUSG00195041586	protein coding gene	Chr8:16518740-16520937 (+)
AKR/J	ENSMUSG00220030427	protein coding gene	Chr8:16288010-16290235 (+)
BALB/cJ	ENSMUSG00180024095	protein coding gene	Chr8:16139096-16141287 (+)
C3H/HeJ	ENSMUSG00175036739	protein coding gene	Chr8:16317149-16319346 (+)
C57BL/6NJ	ENSMUSG00215023665	protein coding gene	Chr8:16260053-16262280 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005017967	protein coding gene	Chr8:16088192-16097892 (+)
CBA/J	ENSMUSG00210041549	protein coding gene	Chr8:16155985-16158178 (+)
DBA/2J	ENSMUSG00185006445	protein coding gene	Chr8:16283785-16285982 (+)
FVB/NJ	ENSMUSG00205017585	protein coding gene	Chr8:16165272-16167469 (+)
JF1/MsJ	ENSUMUG00000031342	protein coding gene	Chr8:16192957-16195144 (+)
LP/J	ENSMUSG00230017986	protein coding gene	Chr8:18368564-18370781 (+)
NOD/ShiLtJ	ENSMUSG00190028876	protein coding gene	Chr8:16288233-16290430 (+)
NZO/HlLtJ	ENSMUSG00225041882	protein coding gene	Chr8:26223460-26225687 (+)
PWK/PhJ	ENSLUMG00010026053	protein coding gene	Chr8:16162996-16165223 (+)
SPRET/EiJ	ENSMSPG00010013133	protein coding gene	Chr8:16400200-16402404 (+)
WSB/EiJ	ENSIUOG00005018481	protein coding gene	Chr8:16229898-16232113 (+)

Homology

• MGI Vertebrate Homology
  Defb46 stringent orthology
  1 mouse;1 rat
  
• Gene Tree
  Defb46
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Genomic Mutations
  1 involving Defb46
• Find Mice (IMSR)
  2 strains or lines available

Expression

• Assay Results
  597

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS40256.1

• Ensembl
  ENSMUSG00000071169 (Evidence)
• NCBI Gene
  574081

Representative Sequences			Length	Strain/Species
genomic	574081	NCBI Gene Model | MGI Sequence Detail	2228	C57BL/6J
transcript	NM_001025351	RefSeq | MGI Sequence Detail	174	Not Specified
polypeptide	NP_001020522	RefSeq | MGI Sequence Detail	57	Not Specified

Protein
Information

• UniProt
  2 Sequences

Molecular
Reagents

• 
  

  Microarray probesets 1

References

• Summaries
  All 11

  Phenotypes 1
• Earliest
  J:101568 Patil AA, et al., Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17
• Latest
  J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662