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Tmem217 Gene Detail
Summary
  • Symbol
    Tmem217
  • Name
    transmembrane protein 217
  • Synonyms
    4933413N12Rik, EG622644
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646280
    NCBI Gene: 71138
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29744983-29768567 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.42 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    777 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646280
 protein coding gene Chr17:29744981-29771359 (-)
129S1/SvImJ ENSMUSG00200053656
 protein coding gene Chr17:25399983-25426407 (-)
A/J ENSMUSG00195051427
 protein coding gene Chr17:26215971-26247622 (-)
AKR/J ENSMUSG00220049414
 protein coding gene Chr17:25263659-25295313 (-)
BALB/cJ ENSMUSG00180041257
 protein coding gene Chr17:25702529-25728959 (-)
C3H/HeJ ENSMUSG00175049830
 protein coding gene Chr17:25251893-25283532 (-)
C57BL/6NJ ENSMUSG00215051490
 protein coding gene Chr17:25261079-25287459 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021346
 protein coding gene Chr17:25389879-25418177 (-)
CAST/EiJ ENSTCUG00005046549
 protein coding gene Chr17:25983748-26010486 (-)
CBA/J ENSMUSG00210050637
 protein coding gene Chr17:25090351-25121995 (-)
DBA/2J ENSMUSG00185039172
 protein coding gene Chr17:27306131-27332561 (-)
FVB/NJ ENSMUSG00205052143
 protein coding gene Chr17:25574476-25600863 (-)
JF1/MsJ ENSUMUG00000056558
 protein coding gene Chr17:26773761-26800728 (-)
LP/J ENSMUSG00230055055
 protein coding gene Chr17:28825736-28852153 (-)
NOD/ShiLtJ ENSMUSG00190047755
 protein coding gene Chr17:25210926-25237358 (-)
NZO/HlLtJ ENSMUSG00225051415
 protein coding gene Chr17:30804366-30830801 (-)
PWK/PhJ ENSLUMG00010034994
 protein coding gene Chr17:24689974-24716794 (-)
SPRET/EiJ ENSMSPG00010049351
 protein coding gene Chr17:25981109-25998884 (-)
WSB/EiJ ENSIUOG00005040820
 protein coding gene Chr17:25970695-25997058 (-)



Homology
more
  • Human Ortholog
    TMEM217, transmembrane protein 217
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM217, transmembrane protein 217
  • Synonyms
    C6orf128, dJ355M6.2
  • Links
    NCBI Gene ID: 221468
    UniProt: Q8N7C4

  • Chr Location
    6p21.2; chr6:37212180-37258155 (-)  GRCh38
  • Human Ortholog
    TMEM217B, transmembrane protein 217B
  • Links
    NCBI Gene ID: 121725057
    UniProt: A0A494BZU4

  • Chr Location
    6p21.2; chr6:37212181-37258144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility due to reduced cAMP production in sperm, hairpin sperm flagellum, and sperm motility defects.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71138 NCBI Gene Model | MGI Sequence Detail 23585 C57BL/6J ±  kb
    transcript NM_001162901 RefSeq | MGI Sequence Detail 928 C57BL/6  
    polypeptide Q14AF1 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR027862 Protein of unknown function DUF4534
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1918388
    References
    more
    • Summaries
      All 22
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:383008 Iida-Norita R, et al., Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility. Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2513924122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory