Cstdc4 MGI Mouse Gene Detail - MGI:3645124 - cystatin domain containing 4

Symbol

Cstdc4
Name

cystatin domain containing 4
Synonyms

Gm5483

Feature Type

protein coding gene
IDs

MGI:3645124
NCBI Gene: 433016
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:36004582-36008481 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM
Mapping Data

1 experiment

SNPs within 2kb

79 from dbSNP Build 142
Strain Annotations

12

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3645124	protein coding gene	Chr16:36004582-36008481 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022782	protein coding gene	Chr16:34576838-34580693 (+)
A/J	MGP_AJ_G0022747	protein coding gene	Chr16:32882648-32886501 (+)
AKR/J	MGP_AKRJ_G0022723	protein coding gene	Chr16:34121630-34126695 (+)
BALB/cJ	MGP_BALBcJ_G0022748	protein coding gene	Chr16:33020153-33024028 (+)
C3H/HeJ	MGP_C3HHeJ_G0022513	protein coding gene	Chr16:34215821-34219696 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022482	protein coding gene	Chr16:36810687-36820890 (+)
DBA/2J	MGP_DBA2J_G0022616	protein coding gene	Chr16:32719147-32723014 (+)
FVB/NJ	MGP_FVBNJ_G0022592	protein coding gene	Chr16:32711423-32715294 (+)
LP/J	MGP_LPJ_G0022683	protein coding gene	Chr16:34310965-34314836 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022611	protein coding gene	Chr16:36012137-36016010 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023210	protein coding gene	Chr16:34105537-34109408 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

CSTA, cystatin A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTA, cystatin A
Synonyms

AREI, PSS4, STF1, STFA
Links

HGNC:2481

NCBI Gene ID: 1475

neXtProt AC: NX_P01040

UniProt: P01040
Chr Location

3q21.1; chr3:122325248-122341969 (+) GRCh38

MGI Vertebrate Homology

Cstdc4 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CSTA
Gene Tree

Cstdc4

Diseases

1 with human CSTA associations

				Human Disease	Mouse Models
				peeling skin syndrome IDs peeling skin syndrome DOID:0060283 MESH:C564818 OMIM:PS270300 ORDO:817 UMLS_CUI:C1849193

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype reference

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

15
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

24
RefSeq

2
UniProt

1
CCDS

CCDS37328.1

Ensembl

ENSMUSG00000079597 (Evidence)
NCBI Gene

433016

			Length	Strain/Species	Flank
genomic	433016	NCBI Gene Model \| MGI Sequence Detail	3900	C57BL/6J	± kb
transcript	NM_001082547	RefSeq \| MGI Sequence Detail	414	C57BL/6
polypeptide	NP_001076016	RefSeq \| MGI Sequence Detail	97	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR001713 Proteinase inhibitor I25A, stefin

IPR018073 Proteinase inhibitor I25, cystatin, conserved site

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All nucleic 3

cDNA 3

Summaries

All 10

Gene Ontology 2

Phenotypes 1
Earliest

J:23000 MGD Nomenclature Committee, Nomenclature Committee Use. 1995-02-14;
Latest

J:293217 GemPharmatech, GemPharmatech Website. 2020;

TSS for Cstdc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138255	Chr16:36004452-36004465 (+)	-123 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23