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Ace3 Gene Detail
Summary
  • Symbol
    Ace3
  • Name
    angiotensin I converting enzyme 3
  • Synonyms
    EG217246
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644400
    NCBI Gene: 217246
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105885501-105896269 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644400
 protein coding gene Chr11:105885424-105898376 (+)
129S1/SvImJ ENSMUSG00200031358
 protein coding gene Chr11:103198012-103208765 (+)
A/J ENSMUSG00195018393
 protein coding gene Chr11:102892470-102903232 (+)
AKR/J ENSMUSG00220031067
 protein coding gene Chr11:103110122-103120869 (+)
BALB/cJ ENSMUSG00180016860
 protein coding gene Chr11:103219387-103230134 (+)
C3H/HeJ ENSMUSG00175011972
 protein coding gene Chr11:103168497-103179243 (+)
C57BL/6NJ ENSMUSG00215006790
 protein coding gene Chr11:102731074-102741841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017306
 protein coding gene Chr11:101906407-101917375 (+)
CAST/EiJ ENSTCUG00005034592
 protein coding gene Chr11:102640145-102650876 (+)
CBA/J ENSMUSG00210013615
 protein coding gene Chr11:102877409-102888161 (+)
DBA/2J ENSMUSG00185018611
 protein coding gene Chr11:103218318-103229065 (+)
FVB/NJ ENSMUSG00205034447
 protein coding gene Chr11:103023771-103034518 (+)
JF1/MsJ ENSUMUG00000020019
 protein coding gene Chr11:103479701-103490426 (+)
LP/J ENSMUSG00230031512
 protein coding gene Chr11:104270485-104281236 (+)
NOD/ShiLtJ ENSMUSG00190019303
 protein coding gene Chr11:103216778-103227529 (+)
NZO/HlLtJ ENSMUSG00225052111
 protein coding gene Chr11:106306488-106317240 (+)
PWK/PhJ ENSLUMG00010016150
 protein coding gene Chr11:103002827-103013535 (+)
SPRET/EiJ ENSMSPG00010035243
 protein coding gene Chr11:103519497-103530315 (+)
WSB/EiJ ENSIUOG00005017547
 protein coding gene Chr11:103002805-103013548 (+)



Homology
more
  • Human Ortholog
    ACE3P, angiotensin I converting enzyme 3, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACE3P, angiotensin I converting enzyme 3, pseudogene
  • Synonyms
    ACE3
  • Links
    NCBI Gene ID: 100129123

  • Chr Location
    17q23.3; chr17:63507034-63519827 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Male mice homozygous for a knock-out allele exhibit normal sperm number, motility, and fertilization ability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000101605 Ensembl Gene Model | MGI Sequence Detail 10769 C57BL/6J ±  kb
transcript ENSMUST00000190995 Ensembl | MGI Sequence Detail 2214 Not Applicable  
polypeptide ENSMUSP00000140827 Ensembl | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001548 Peptidase M2, peptidyl-dipeptidase A
  • GlyGen
    D0G895 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3
References
more
  • Summaries
    All 18
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:123156 Rella M, et al., Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. BMC Genomics. 2007;8:194
  • Latest
    J:296796 Giani JF, et al., Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity. Kidney Int. 2017 Apr;91(4):856-867
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory