Insyn2b MGI Mouse Gene Detail - MGI:3643491 - inhibitory synaptic factor family member 2B

Symbol

Insyn2b
Name

inhibitory synaptic factor family member 2B
Synonyms

Fam196b, Gm6041

Feature Type

protein coding gene
IDs

MGI:3643491
NCBI Gene: 574403
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:34264822-34372642 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.72 cM
Mapping Data

1 experiment

SNPs within 2kb

626 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643491	protein coding gene	Chr11:34264758-34372642 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018152	protein coding gene	Chr11:32649117-32765329 (+)
A/J	MGP_AJ_G0018125	protein coding gene	Chr11:31423096-31532838 (+)
AKR/J	MGP_AKRJ_G0018089	protein coding gene	Chr11:32388897-32495523 (+)
BALB/cJ	MGP_BALBcJ_G0018094	protein coding gene	Chr11:31597155-31705938 (+)
C3H/HeJ	MGP_C3HHeJ_G0017907	protein coding gene	Chr11:32338510-32452714 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018548	protein coding gene	Chr11:33687297-33800262 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016203	protein coding gene	Chr11:29911752-30018192 (+)
CAST/EiJ	MGP_CASTEiJ_G0017471	protein coding gene	Chr11:32451144-32566694 (+)
CBA/J	MGP_CBAJ_G0017880	protein coding gene	Chr11:35357810-35482692 (+)
DBA/2J	MGP_DBA2J_G0017990	protein coding gene	Chr11:31183711-31291154 (+)
FVB/NJ	MGP_FVBNJ_G0017984	protein coding gene	Chr11:31015665-31125840 (+)
LP/J	MGP_LPJ_G0018062	protein coding gene	Chr11:32914745-33021825 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018008	protein coding gene	Chr11:36248377-36360407 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018587	protein coding gene	Chr11:32548084-32662993 (+)
PWK/PhJ	MGP_PWKPhJ_G0017252	protein coding gene	Chr11:31377187-31486707 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017044	protein coding gene	Chr11:32281977-32389716 (+)
WSB/EiJ	MGP_WSBEiJ_G0017520	protein coding gene	Chr11:32184992-32295928 (+)

Human Ortholog

INSYN2B, inhibitory synaptic factor family member 2B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSYN2B, inhibitory synaptic factor family member 2B
Synonyms

C5orf57, FAM196B
Links

HGNC:37271

NCBI Gene ID: 100131897

neXtProt AC: NX_A6NMK8

UniProt: A6NMK8
Chr Location

5q35.1; chr5:169861303-169980495 (-) GRCh38

MGI Vertebrate Homology

Insyn2b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: INSYN2B
Gene Tree

Insyn2b

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Insyn2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

5
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

4
UniProt

1
CCDS

CCDS36127.1

Ensembl

ENSMUSG00000069911 (Evidence)
NCBI Gene

574403

			Length	Strain/Species	Flank
genomic	574403	NCBI Gene Model \| MGI Sequence Detail	107821	C57BL/6J	± kb
transcript	NM_001025382	RefSeq \| MGI Sequence Detail	5371	C57BL/6
polypeptide	Q6GQV1	UniProt \| EBI \| MGI Sequence Detail	535	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031417 protein INSYN2B

(term hierarchy)
InterPro Domains

IPR029337 Inhibitory synaptic factor 2

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All nucleic 11

cDNA 7

Primer pair 3

Other 1

Microarray probesets 2

Summaries

All 23

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 6
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:204883 Feenstra JM, et al., Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ. 2012 May;54(4):451-62

TSS for Insyn2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100925	Chr11:34264757-34264786 (+)	-50 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23