krtap20-23 Gene Detail

Summary

• Symbol
  krtap20-23
• Name
  keratin associated protein 20-23
• Synonyms
  Gm6358

• Feature Type
  protein coding gene
• IDs
  MGI:3643237
  NCBI Gene: 102637070
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr16:88937832-88937987 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, 51.42 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  186 from dbSNP Build 142
• Strain Annotations
  16

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643237	protein coding gene	Chr16:88937739-88938227 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023012	protein coding gene	Chr16:89996783-89997271 (+)
A/J	MGP_AJ_G0022980	protein coding gene	Chr16:85813255-85813743 (+)
AKR/J	MGP_AKRJ_G0022950	protein coding gene	Chr16:88434349-88434945 (+)
BALB/cJ	MGP_BALBcJ_G0022982	protein coding gene	Chr16:86346916-86347404 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0023429	protein coding gene	Chr16:92875142-92875630 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020932	protein coding gene	Chr16:83594748-83595239 (+)
CAST/EiJ	MGP_CASTEiJ_G0022263	protein coding gene	Chr16:89446611-89447089 (+)
CBA/J	MGP_CBAJ_G0022712	protein coding gene	Chr16:96849596-96850084 (+)
DBA/2J	MGP_DBA2J_G0022846	protein coding gene	Chr16:85743252-85743740 (+)
FVB/NJ	MGP_FVBNJ_G0022821	protein coding gene	Chr16:84843614-84844102 (+)
LP/J	MGP_LPJ_G0022916	protein coding gene	Chr16:89688077-89688565 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022841	protein coding gene	Chr16:101434262-101435814 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023447	protein coding gene	Chr16:88923329-88923817 (+)
PWK/PhJ	MGP_PWKPhJ_G0022007	protein coding gene	Chr16:85894894-85895382 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021839	protein coding gene	Chr16:88464871-88465368 (+)
WSB/EiJ	no annotation

Homology

• Human Ortholog
  KRTAP20-2, keratin associated protein 20-2

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP20-2, keratin associated protein 20-2
  
• Synonyms
  KAP20.2
• Links
  HGNC:18944

  NCBI Gene ID: 337976

  UniProt: Q3LI61

  
  
• Chr Location
  21q22.11; chr21:30635206-30635619 (+)  GRCh38

---

• MGI Vertebrate Homology
  krtap20-23 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: KRTAP20-2
• Gene Tree
  krtap20-23
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  2
• Genomic Mutations
  3 involving krtap20-23
• Find Mice (IMSR)
  3 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  2
• UniProt
  2

• Ensembl
  ENSMUSG00000068071 (Evidence)
• NCBI Gene
  102637070

Representative Sequences			Length	Strain/Species
genomic	102637070	NCBI Gene Model | MGI Sequence Detail	156	C57BL/6J
transcript	NM_001436273	RefSeq | MGI Sequence Detail	213	C57BL/6
polypeptide	NP_001423202	RefSeq | MGI Sequence Detail	51	C57BL/6

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR052878 Keratin-associated matrix protein
  IPR021743 Keratin-associated protein, type8/19/20/21/22

Molecular
Reagents

• 
  

  Microarray probesets 1

Other
Accession IDs

MGI:3641828, MGI:7593859

References

• Summaries
  All 15

  Phenotypes 7
• Earliest
  J:117029 Davisson M, et al., Impact of trisomy on fertility and meiosis in male mice. Hum Reprod. 2007 Feb;22(2):468-76
• Latest
  J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for krtap20-23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139254	Chr16:88937772-88937777 (+)	-57 bp