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Ddx43 Gene Detail
Summary
  • Symbol
    Ddx43
  • Name
    DEAD box helicase 43
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 43, ENSMUSG00000070291, OTTMUSG00000019690
Location &
Maps
more
  • Sequence Map
    Chr9:78303059-78330869 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    867 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642857
 protein coding gene Chr9:78303059-78330871 (+)
129S1/SvImJ ENSMUSG00200018999
 protein coding gene Chr9:75453841-75481878 (+)
A/J ENSMUSG00195009763
 protein coding gene Chr9:75238183-75266000 (+)
AKR/J ENSMUSG00220014659
 protein coding gene Chr9:75344519-75372331 (+)
BALB/cJ ENSMUSG00180017060
 protein coding gene Chr9:75351723-75379535 (+)
C3H/HeJ ENSMUSG00175011473
 protein coding gene Chr9:75410579-75438391 (+)
C57BL/6NJ ENSMUSG00215007442
 protein coding gene Chr9:75289844-75317659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032467
 protein coding gene Chr9:75408222-75435667 (+)
CAST/EiJ ENSTCUG00005008889
 protein coding gene Chr9:74988981-75017537 (+)
CBA/J ENSMUSG00210013233
 protein coding gene Chr9:75443500-75471314 (+)
DBA/2J ENSMUSG00185006481
 protein coding gene Chr9:75471816-75499628 (+)
FVB/NJ ENSMUSG00205023986
 protein coding gene Chr9:75632525-75660334 (+)
JF1/MsJ ENSUMUG00000029062
 protein coding gene Chr9:75376048-75404734 (+)
LP/J ENSMUSG00230024754
 protein coding gene Chr9:75605438-75633475 (+)
NOD/ShiLtJ ENSMUSG00190024796
 protein coding gene Chr9:75547890-75575704 (+)
NZO/HlLtJ ENSMUSG00225024715
 protein coding gene Chr9:75769766-75797578 (+)
PWK/PhJ ENSLUMG00010015211
 protein coding gene Chr9:75309187-75337777 (+)
SPRET/EiJ ENSMSPG00010003869
 protein coding gene Chr9:76540861-76566692 (+)
WSB/EiJ ENSIUOG00005023521
 protein coding gene Chr9:74876450-74904276 (+)



Homology
more
  • Human Ortholog
    DDX43, DEAD-box helicase 43
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX43, DEAD-box helicase 43
  • Synonyms
    CT13, HAGE
  • Links
    NCBI Gene ID: 55510
    UniProt: Q9NXZ2

  • Chr Location
    6q13; chr6:73394828-73417566 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070291 Ensembl Gene Model | MGI Sequence Detail 27811 C57BL/6J ±  kb
transcript ENSMUST00000113367 Ensembl | MGI Sequence Detail 2207 Not Applicable  
polypeptide ENSMUSP00000108994 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    3.6.4.13
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH-box helicase domain
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR036612 K Homology domain, type 1 superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory