About   Help   FAQ
Hottip Gene Detail
Summary
  • Symbol
    Hottip
  • Name
    Hoxa distal transcript antisense RNA
  • Synonyms
    ENSMUSG00000055408, Gm15053
Location &
Maps
more
  • Sequence Map
    Chr6:52239760-52244588 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642509
 lncRNA gene Chr6:52239760-52244588 (+)
129S1/SvImJ ENSMUSG00200005424
 lncRNA gene Chr6:49217043-49221871 (+)
A/J ENSMUSG00195006899
 lncRNA gene Chr6:48940962-48945793 (+)
AKR/J ENSMUSG00220004869
 lncRNA gene Chr6:48650053-48654883 (+)
BALB/cJ ENSMUSG00180027384
 lncRNA gene Chr6:49242689-49247525 (+)
C3H/HeJ ENSMUSG00175018394
 lncRNA gene Chr6:49009287-49014113 (+)
C57BL/6NJ ENSMUSG00215011052
 lncRNA gene Chr6:49193545-49198373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0006345
 lincRNA gene Chr6:46746141-46750920 (+)
CAST/EiJ ENSTCUG00005005016
 lncRNA gene Chr6:48499693-48504467 (+)
CBA/J ENSMUSG00210018782
 lncRNA gene Chr6:49053609-49058435 (+)
DBA/2J ENSMUSG00185014115
 lncRNA gene Chr6:49635831-49640657 (+)
FVB/NJ ENSMUSG00205029266
 lncRNA gene Chr6:49293914-49298748 (+)
JF1/MsJ ENSUMUG00000013192
 lncRNA gene Chr6:49008659-49013480 (+)
LP/J ENSMUSG00230019842
 lncRNA gene Chr6:50714333-50719159 (+)
NOD/ShiLtJ ENSMUSG00190037935
 lncRNA gene Chr6:48970977-48975804 (+)
NZO/HlLtJ ENSMUSG00225013873
 lncRNA gene Chr6:52698329-52703155 (+)
PWK/PhJ ENSLUMG00010021516
 lncRNA gene Chr6:48745769-48750597 (+)
SPRET/EiJ ENSMSPG00010009954
 lncRNA gene Chr6:49329561-49334360 (+)
WSB/EiJ ENSIUOG00005027928
 lncRNA gene Chr6:49316391-49321219 (+)



Homology
more
  • Human Ortholog
    HOTTIP, HOXA distal transcript antisense RNA
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOTTIP, HOXA distal transcript antisense RNA
  • Synonyms
    HOXA13-AS1, HOXA-AS6, NCRNA00213
  • Links
    NCBI Gene ID: 100316868

  • Chr Location
    7p15.2; chr7:27198575-27207259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit limb grasping, decreased grip strength, muscle weakness, decreased gastrocnemius weight with a significant reduction in the number of muscle fibers, and shortened calcanea.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    8
  • cDNA Data
    3
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      28
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 791364 NCBI Gene Model | MGI Sequence Detail 4829 C57BL/6J ±  kb
    transcript NR_110441 RefSeq | MGI Sequence Detail 2879 C57BL/6  
    polypeptide Q8CCA9 UniProt | EBI | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 3
      Other 1
    References
    more
    • Summaries
      All 18
      Developmental Gene Expression 4
      Phenotypes 4
    • Earliest
      J:204277 Sauvageau M, et al., Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013;2(0):e01749
    • Latest
      J:369605 Wang H, et al., LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitinproteasome degradation of p53. Cell Death Dis. 2025 Jul 7;16(1):502
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory