Gm15441 Gene Detail

Summary

• Symbol
  Gm15441
• Name
  predicted gene 15441
• Synonyms
  ENSMUSG00000074398

• Feature Type
  lncRNA gene
• IDs
  MGI:3641753
  NCBI Gene: 100038464
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr3:96463084-96474117 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 41.93 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  328 from dbSNP Build 142
• Strain Annotations
  31

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3641753	lncRNA gene	Chr3:96462168-96474162 (-)
129S1/SvImJ	ENSMUSG00200045662	lncRNA gene	Chr3:93091678-93102721 (-)
129S1/SvImJ	ENSMUSG00200039978	protein coding gene	Chr3:93091644-93093832 (-)
A/J	ENSMUSG00195041611	protein coding gene	Chr3:93495137-93497314 (-)
A/J	ENSMUSG00195048318	lncRNA gene	Chr3:93495171-93506230 (-)
AKR/J	ENSMUSG00220041757	lncRNA gene	Chr3:91840864-91851914 (-)
AKR/J	ENSMUSG00220040438	protein coding gene	Chr3:91840830-91843017 (-)
BALB/cJ	ENSMUSG00180042895	lncRNA gene	Chr3:93437131-93448175 (-)
BALB/cJ	ENSMUSG00180038324	protein coding gene	Chr3:93437097-93439287 (-)
C3H/HeJ	ENSMUSG00175028056	protein coding gene	Chr3:93053560-93055737 (-)
C3H/HeJ	ENSMUSG00175030225	lncRNA gene	Chr3:93053594-93064650 (-)
C57BL/6NJ	ENSMUSG00215018640	protein coding gene	Chr3:93818226-93820413 (-)
C57BL/6NJ	ENSMUSG00215039160	lncRNA gene	Chr3:93818260-93829311 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003408	antisense lncRNA gene	Chr3:90600131-90610890 (-)
CAST/EiJ	ENSTCUG00005020577	lncRNA gene	Chr3:93637832-93648884 (-)
CBA/J	ENSMUSG00210050558	protein coding gene	Chr3:93606592-93608769 (-)
CBA/J	ENSMUSG00210051544	lncRNA gene	Chr3:93606626-93617682 (-)
DBA/2J	ENSMUSG00185038949	protein coding gene	Chr3:94059261-94061448 (-)
DBA/2J	ENSMUSG00185045041	lncRNA gene	Chr3:94059295-94070345 (-)
FVB/NJ	ENSMUSG00205043102	protein coding gene	Chr3:92714973-92717150 (-)
FVB/NJ	ENSMUSG00205050551	lncRNA gene	Chr3:92715007-92726064 (-)
JF1/MsJ	ENSUMUG00000048287	lncRNA gene	Chr3:92902995-92914087 (-)
LP/J	ENSMUSG00230043160	protein coding gene	Chr3:96023488-96025675 (-)
LP/J	ENSMUSG00230045822	lncRNA gene	Chr3:96023522-96034565 (-)
NOD/ShiLtJ	ENSMUSG00190036515	protein coding gene	Chr3:94152196-94154383 (-)
NOD/ShiLtJ	ENSMUSG00190048586	lncRNA gene	Chr3:94152230-94163282 (-)
NZO/HlLtJ	ENSMUSG00225010113	protein coding gene	Chr3:98402335-98404525 (-)
NZO/HlLtJ	ENSMUSG00225012275	lncRNA gene	Chr3:98402369-98413412 (-)
PWK/PhJ	ENSLUMG00010032702	lncRNA gene	Chr3:92895573-92906668 (-)
SPRET/EiJ	ENSMSPG00010046932	lncRNA gene	Chr3:93193486-93204553 (-)
WSB/EiJ	ENSIUOG00005034259	lncRNA gene	Chr3:93553586-93564645 (-)

Homology

• Gene Tree
  Gm15441
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  3 phenotypes from multigenic genotypes
  10 phenotype references
  

• All Mutations and Alleles
  75
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  70
• Radiation induced
  1
• Genomic Mutations
  2 involving Gm15441
• Find Mice (IMSR)
  9 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous knockout leads to upregulation, after fasting, of the inflammasome pathway and increases lipid accumulation in the liver after fasting.

Expression

• Assay Results
  597
• cDNA Data
  5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  56
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000074398 (Evidence)
• NCBI Gene
  100038464

Representative Sequences			Length	Strain/Species
genomic	100038464	NCBI Gene Model | MGI Sequence Detail	11034	C57BL/6J
transcript	NR_040409	RefSeq | MGI Sequence Detail	1673	C57BL/6
polypeptide	Q3UPP6	UniProt | EBI | MGI Sequence Detail	68	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 2

References

• Summaries
  All 22

  Diseases 1

  Phenotypes 10
• Earliest
  J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• Latest
  J:299830 Brocker CN, et al., Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020 Nov 17;11(1):5847

TSS for Gm15441:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34628	Chr3:96465105-96465118 (-)	9,005 bp
Tssr34627	Chr3:96464955-96465015 (-)	9,132 bp
Tssr34626	Chr3:96463566-96463573 (-)	10,547 bp